Evidence map›Paper›PMID 39636449›Full record

ArticleAngiogenesis2024

Inhibition of Angiopoietin-2 rescues sporadic brain arteriovenous malformations by reducing pericyte loss.

Tianqi Tu, Shikun Zhang, Jingwei Li, Chendan Jiang, Jian Ren, Shiju Zhang, Xiaosheng Meng, Hao Peng, Dong Xing, Hongqi Zhang and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Angiogenesis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Endothelial mitochondria in the blood-brain barrier.Fluids and barriers of the CNS · 2025
    Review
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tianqi TuDepartment of Neurosurgery, Xuanwu Hospital, International Neuroscience Institute, Capital Medical University, Beijing, 100053, China.
Shikun ZhangDepartment of Neurosurgery, Xuanwu Hospital, International Neuroscience Institute, Capital Medical University, Beijing, 100053, China.
Jingwei LiDepartment of Neurosurgery, Xuanwu Hospital, International Neuroscience Institute, Capital Medical University, Beijing, 100053, China.
Chendan JiangDepartment of Neurosurgery, Xuanwu Hospital, International Neuroscience Institute, Capital Medical University, Beijing, 100053, China.
Jian RenDepartment of Neurosurgery, Xuanwu Hospital, International Neuroscience Institute, Capital Medical University, Beijing, 100053, China.
Shiju ZhangDepartment of Neurosurgery, Xuanwu Hospital, International Neuroscience Institute, Capital Medical University, Beijing, 100053, China.
Xiaosheng MengDepartment of Neurosurgery, Xuanwu Hospital, International Neuroscience Institute, Capital Medical University, Beijing, 100053, China.
Hao PengDepartment of Neurosurgery in Hainan General Hospital, Hainan Medical University, Hainan, China.
Dong XingBiomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University, Beijing, China.
Hongqi Zhang *Department of Neurosurgery, Xuanwu Hospital, International Neuroscience Institute, Capital Medical University, Beijing, 100053, China. xwzhanghq@163.com.
Tao Hong *Department of Neurosurgery, Xuanwu Hospital, International Neuroscience Institute, Capital Medical University, Beijing, 100053, China. hongtao.edu@gmail.com.
Jiaxing Yu *Department of Neurosurgery, Xuanwu Hospital, International Neuroscience Institute, Capital Medical University, Beijing, 100053, China. xwyujiaxing@163.com.

Funding

Beijing Municipal Education Commission BPHR20220113Beijing Physician Scientist Training Project BJPSTP-2024-26Hainan Science and Technology Project ZDYF2021SHFZ111National Natural Science Foundation of China 82101369National Natural Science Foundation of China 82201439National Natural Science Foundation of China 82220108010National Natural Science Foundation of China 82330038
6 · The paper itself

Abstract

Brain arteriovenous malformations (bAVMs) are a major cause of hemorrhagic stroke in children and young adults. These lesions are thought to result from somatic KRAS/BRAF mutations in brain endothelial cells (bECs). In this study, we introduce a new bAVM model by inducing a brain endothelial-specific Braf

Indexed as

Angiopoietin-2Intracranial Arteriovenous MalformationsPericytesAnimalsEndothelial CellsHumansMiceMutationProto-Oncogene Proteins B-rafRibonuclease, PancreaticAng2 protein, mouseAngiopoietin-2Angpt2 protein, mouseProto-Oncogene Proteins B-rafRibonuclease, PancreaticANGPT-2BRAFEndothelial cellPericytesSomatic mutation

Identifiers

PMID39636449

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.