Evidence map›Paper›PMID 39637179›Full record

ArticleEpigenetics2024

Epigenetic aging of semen is associated with inflammation.

Junxi Feng, Liudmilla Rubbi, Reza Kianian, Jesse Nelson Mills, Vadim Osadchiy, John Tucker Sigalos, Sriram Venkata Eleswarapu, Matteo Pellegrini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Junxi FengMolecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA ,USA.
Liudmilla RubbiMolecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA ,USA.
Reza KianianDivision of Andrology, Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Jesse Nelson MillsDivision of Andrology, Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Vadim OsadchiyDivision of Andrology, Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
John Tucker SigalosDivision of Andrology, Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Sriram Venkata EleswarapuDivision of Andrology, Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Matteo PellegriniMolecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA ,USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Male infertility has been a primary cause of global infertility, affecting 8-12% of couples worldwide. Previous studies have shown that semen quality decreases with advanced aging with an increased presence of inflammatory cells. In this study, we examined changes in the epigenome across a diverse cohort that includes both fertile and infertile men. We also compare the age-associated changes in semen to those observed in buccal swabs in order to characterize differences in epigenetic aging across diverse tissues. We found that variations in the semen methylome associated with aging are linked to inflammatory genes. Many age-associated sites are demethylated with advanced aging and are associated with the activation of inflammatory pathways. By contrast, we do not observe age-associated changes in inflammatory genes in buccal swab methylomes, which instead are characterized by changes to bivalent promoters. Our findings highlight the potential of epigenetic markers as indicators of male reproductive health.

Indexed as

AgingDNA MethylationEpigenesis, GeneticInflammationSemenAdultEpigenomeHumansInfertility, MaleMaleMiddle AgedagingEpigeneticsmale infertilitysemensperm

Identifiers

PMID39637179
PMCPMC11622584

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.