Evidence map›Paper›PMID 39637721›Full record

ArticleJournal of psychiatric research2025

Threat sensitivity mediates the association between perceived safety and anxiety in adolescents from urban communities.

Carmen Carpenter, Autumm R Heeter, MacKenna M Shampine, Leah C Gowatch, Samantha L Ely, Amanpreet Bhogal, Emilie-Clare L O'Mara, Clara G Zundel, Nina M Lipanski, Breanna A Borg and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Carmen CarpenterDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address: hd0028@wayne.edu.
Autumm R HeeterCollege of Medicine, Central Michigan University, Mount Pleasant, MI, USA. Electronic address: heete1a@cmich.edu.
MacKenna M ShampineDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address: mackenna.shampine@wayne.edu.
Leah C GowatchDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address: leah.gowatch@wayne.edu.
Samantha L ElyDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA; Translational Neuroscience Program, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address: samanthaely@wayne.edu.
Amanpreet BhogalDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address: amanpreet.bhogal@wayne.edu.
Emilie-Clare L O'MaraDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address: eclomara@wayne.edu.
Clara G ZundelDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address: clara.zundel@wayne.edu.
Nina M LipanskiDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address: nlipansk@ucsd.edu.
Breanna A BorgDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA; Department of Family Medicine & Public Health Sciences, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address: breanna.borg@wayne.edu.
Sharon MarshallDepartment of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA; Wayne Pediatrics, Detroit, MI, USA. Electronic address: smarshal@med.wayne.edu.
Laura J BenjaminsDepartment of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA; Wayne Pediatrics, Detroit, MI, USA. Electronic address: laura.benjamins@wayne.edu.
Hannah SchacterDepartment of Psychology, Wayne State University, Detroit, MI, USA; Merrill Palmer Skillman Institute, Wayne State University, Detroit, MI, USA. Electronic address: hannah.schacter@wayne.edu.
Christopher YoungmanDepartment of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA; Wayne Pediatrics, Detroit, MI, USA. Electronic address: cyoungman@med.wayne.edu.
Hilary A MarusakDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA; Translational Neuroscience Program, Wayne State University School of Medicine, Detroit, MI, USA; Merrill Palmer Skillman Institute, Wayne State University, Detroit, MI, USA; Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address: hmarusak@med.wayne.edu.

Funding

Exercise facilitation of adolescent fear extinction, frontolimbic circuitry, and endocannabinoidsR01MH132830 · NIMH · WAYNE STATE UNIVERSITY · PI Hilary Marusak · 2023 to 2026
$2.9M
Endocannabinoids and the development of extinction recall neural circuitry in adolescentsK01MH119241 · NIMH · WAYNE STATE UNIVERSITY · PI MARUSAK, HILARY · 2019 to 2023
$842k
Effects of peer victimization on physiological markers of threat sensitivity in adolescentsR21HD105882 · NICHD · WAYNE STATE UNIVERSITY · PI MARUSAK, HILARY, SCHACTER, HANNAH L · 2022 to 2023
$424k
NICHD NIH HHS R21 HD105882NIMH NIH HHS K01 MH119241NIMH NIH HHS R01 MH132830
6 · The paper itself

Abstract

purposeDespite the prevalence of violence exposure (VE) among youth and its link to increased risk for anxiety and related psychiatric disorders, few studies have examined potential mediators. The present study investigated the relationships among lifetime VE, perceived safety, threat sensitivity, and anxiety symptoms in adolescents from an urban minority community (Detroit, MI).

methodsA sample of 54 adolescents (ages 14-18, 55.6% female) self-reported on VE, safety, threat sensitivity, and anxiety symptoms in an online survey. Linear regression analyses were conducted to examine the associations among these variables.

resultsResults indicated that perceived safety, but not VE, was significantly associated with lower anxiety and threat sensitivity. Furthermore, threat sensitivity mediated the association between perceived safety and anxiety symptoms. DISCUSSION: The findings of the present study highlight (1) the potential protective role of perceived safety and (2) threat sensitivity as a potential target for disrupting anxiety-related pathways in adolescents with VE.

Indexed as

AnxietyExposure to ViolenceFearSafetyUrban PopulationAdolescentFemaleHumansMaleMichiganSelf ReportAnxiety disordersEarly adversityStressViolenceYouth

Identifiers

PMID39637721
PMCPMC11750585

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.