Evidence map›Paper›PMID 39638121›Full record

ArticleThe Journal of nutrition2025

The Impact of Sodium Selenite and Seleno-L-Methionine on Stress Erythropoiesis in a Murine Model of Hemolytic Anemia.

Hangdi Gong, Yuting Bai, Dane Rahoi, Robert F Paulson, K Sandeep Prabhu

Abstract read
In one paragraph

Article in The Journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Redox Modulation of Erythropoiesis by Selenoproteins.Biological trace element research · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hangdi GongDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, United States.
Yuting BaiDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, United States.
Dane RahoiDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, United States; Animal Diagnostic Laboratory, Mammalian Pathology Section, Department of Veterinary and Biomedical Sciences. The Pennsylvania State University, University Park, Pennsylvania, United States.
Robert F PaulsonDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, United States. Electronic address: rfp5@psu.edu.
K Sandeep PrabhuDepartment of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, United States. Electronic address: ksp4@psu.edu.

Funding

Selenium, Selenoproteins, and Stress ErythropoiesisR01DK119865 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI PAULSON, ROBERT FRANK, PRABHU, KUMBLE SANDEEP · 2019 to 2021
$1.1M
Metabolic Control of Erythroid DifferentiationR01HL146528 · NHLBI · PENNSYLVANIA STATE UNIVERSITY, THE · PI PAULSON, ROBERT FRANK · 2020 to 2022
$914k
NHLBI NIH HHS R01 HL146528NIDDK NIH HHS R01 DK119865
6 · The paper itself

Abstract

backgroundSelenium (Se) is an essential trace element that exerts most biological activities through selenoproteins. Dietary selenium is a key regulator of red cell homeostasis and stress erythropoiesis. However, it is unknown whether the form and increasing doses of Se supplementation in the diet impact stress erythropoiesis under anemic conditions.

objectivesIf inorganic (sodium selenite; Na

methodsThree-wk-old male C57BL/6 mice were subjected to graded amounts of Se in the form of <0.01 mg/kg Se [Se-deficiency (Se-D)], 0.1 mg/kg Na

resultsPhenotypic parameters showed that supplementing the diet with Se in the form of Na

Indexed as

Anemia, HemolyticErythropoiesisSelenomethionineSodium SeleniteStress, PhysiologicalAnimalsDietary SupplementsDisease Models, AnimalMaleMiceMice, Inbred C57BLSelenomethionineSodium Seleniteburst-forming unit erythroid cellserythroblastic islandsinflammationselenoproteinsstress erythroid progenitors

Identifiers

PMID39638121
PMCPMC11867129

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.