Evidence map›Paper›PMID 39638558›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Direct Modulation of CRH Nerve Terminal Function by Noradrenaline and Corticosterone.

Emmet M Power, Dharshini Ganeshan, Jamieson Paul, Hiroyuki Igarashi, Wataru Inoue, Karl J Iremonger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Tanycytes: bloodhounds of the metabolic brain.Trends in endocrinology and metabolism: TEM · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emmet M PowerCentre for Neuroendocrinology and Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand.
Dharshini GaneshanCentre for Neuroendocrinology and Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand.
Jamieson PaulCentre for Neuroendocrinology and Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand.
Hiroyuki IgarashiRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5B7, Canada.
Wataru InoueRobarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 5B7, Canada.ORCID https://orcid.org/0000-0002-2438-5123
Karl J IremongerCentre for Neuroendocrinology and Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin 9016, New Zealand karl.iremonger@otago.ac.nz.ORCID https://orcid.org/0000-0002-8976-2401

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nerve terminals are the final point of regulation before neurosecretion. As such, neuromodulators acting on nerve terminals can exert significant influence on neural signaling. Hypothalamic corticotropin-releasing hormone (CRH) neurons send axonal projections to the median eminence where CRH is secreted to stimulate the hypothalamic-pituitary-adrenal (HPA) axis. Noradrenaline and corticosterone are two of the most important neuromodulators of HPA axis function; noradrenaline excites CRH neurons and corticosterone inhibits CRH neurons by negative feedback. Here, we used GCaMP6f Ca

Indexed as

CorticosteroneCorticotropin-Releasing HormoneNorepinephrinePresynaptic TerminalsAction PotentialsAnimalsMaleMiceMice, Inbred C57BLNeuronsCorticosteroneCorticotropin-Releasing HormoneNorepinephrinecorticosteroneCRHhypothalamusnerve terminalnoradrenalinestress

Identifiers

PMID39638558
PMCPMC11735660

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.