ArticleBMC psychiatry2024
Association between C-reactive protein-triglyceride glucose index and depressive symptoms in American adults: results from the NHANES 2005 to 2010.
Article in BMC psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed.
- The Correlation Analysis of C-Reactive Protein-Triglyceride-Glucose Index with the Severity of Hyperlipidemic Acute Pancreatitis.Digestive diseases and sciences · 2026Article
- Article
- Metabolic Indices of Atherogenicity, Insulin Resistance, and Inflammation (AIP, TyG, and CTI) and the Risk of Renal Function Decline in Early-Stage CKM Syndrome: A Nationwide Prospective Cohort Study.Journal of clinical medicine · 2026Article
- Association between C-reactive protein-triglyceride glucose index (CTI) and cardiovascular and all-cause mortality risk among the elderly population: insights from three datasets.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Association of high-sensitivity C-reactive protein-triglyceride glucose index and stroke outcomes: results from the China National Stroke Registry III.BMC neurology · 2026Article
- Association of C-reactive protein-triglyceride glucose index and its modified indices with stroke risk in individuals at cardiovascular-kidney-metabolic syndrome stages 0-3: a population-based cohort study.Cardiovascular diabetology · 2026Article
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- The Prognostic Role of C-Reactive Protein-Triglyceride Glucose Index in Predicting Unfavorable Outcomes in Acute Ischemic Stroke: A Large-Scale Cohort Study.Brain and behavior · 2026Article
- Association Between C-Reactive Protein-Triglyceride-Glucose Index and Adverse Prognosis Outcomes in Patients with Acute Myocardial Infarction.Journal of cardiovascular development and disease · 2026Article
- Joint assessment of frailty index and metabolic syndrome score for cardiovascular disease in middle aged and older Chinese adults: insights from a national cohort study 2011-2020.BMC cardiovascular disorders · 2026Article
- Association between the C-reactive protein-triglyceride-glucose index and asthma risk: evidence from the NHANES cohort and validation in the CHNS cohort.Clinics (Sao Paulo, Brazil) · 2026Article
- A novel perspective on adolescent bone health: the role of C-reactive protein-triglyceride-glucose index.Pediatric research · 2026Article
- Association Between C-Reactive Protein-Triglyceride Glucose Index and Depressive Symptoms Among US Adults: A Nationally Representative Cross-Sectional Study From 2005 to 2023.Actas espanolas de psiquiatria · 2026Article
- C-Reactive Protein-Triglyceride-Glucose Index and Coronary Artery Calcium Progression: A Prospective Cohort Analysis.Clinical cardiology · 2026Observational
- Sex differences in the association of the CRP-TyG index with coronary artery disease and long-term mortality in MASLD.Frontiers in endocrinology · 2026Article
- Association between the C-reactive protein-triglyceride-glucose index and major adverse cardiovascular events in patients undergoing percutaneous coronary intervention.Frontiers in medicine · 2026Article
- Article
- The influence of C-reactive protein-triglyceride-glucose index (CTI) on the prognosis of heart failure patients with different ejection fractions.Frontiers in cardiovascular medicine · 2026Article
- Impact of C-reactive protein-triglyceride-glucose and systemic immune-inflammation indices on obstructive sleep apnea in older adults with depression.Frontiers in neuroscience · 2026Article
- Association of C-Reactive Protein-Triglyceride Glucose Index With Chronic Obstructive Pulmonary Disease: Results From the NHANES and CHARLS Cohorts.Mediators of inflammation · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundThe novel serum C-reactive protein-triglyceride glucose index (CTI) has been identified as an ideal parameter that integrates inflammation and insulin resistance, which are potential mechanisms underlying depressive symptoms. Our research aimed to investigate the association between CTI and depressive symptoms.
methodsOur cross-sectional investigation utilized data from the National Health and Nutrition Examination Survey conducted between 2005 and 2010. The integrated CTI was calculated as 0.412 × Ln (C-reactive protein) (mg/dL) + Ln [triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. The severity of depressive symptoms was evaluated through the continuous Patient Health Questionnaire-9 (PHQ-9) scores, and the categorical definition of depressive symptoms (PHQ-9 score ≥ 10) reflected moderate to severe symptoms. Survey-weighted linear and logistic regression models were conducted to establish the correlation between CTI and PHQ-9 scores, and between CTI and depressive symptoms. Moreover, subgroup analyses, interaction tests, and smoothed curve fitting were performed to scrutinize the steadiness of the results.
resultsA total of 5,954 participants were enrolled in our study, including 477 with depressive symptoms and 5,477 without. The results revealed a significant positive relationship between CTI and PHQ-9 scores (β: 0.40, 95% CI: 0.25,0.55, p < 0.001) and depressive symptoms (OR: 1.30, 95% CI: 1.06,1.61, p = 0.02). Additionally, individuals in the fourth quartile of CTI exhibited a higher likelihood of depressive symptoms than those in the first quartile (PHQ-9 score: β: 0.83, 95% CI: 0.39,1.26, p < 0.001; depressive symptoms: OR: 2.00, 95% CI:1.19,3.36, p = 0.01). Smooth curve fitting and subgroup analyses consistently demonstrated the positive relationship.
conclusionsElevated CTI was correlated with a higher risk of depressive symptoms, underscoring CTI as a potential clinical indicator for identifying and stratifying depressive symptoms. CLINICAL TRIAL NUMBER: Not applicable.
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