Evidence map›Paper›PMID 39639867›Full record

ArticleFrontiers in cellular and infection microbiology2024

Integrated analysis of lncRNA and mRNA expression profiles in cutaneous leishmaniasis lesions caused by

Shima Hadifar, Nasrin Masoudzadeh, Björn Andersson, Hossein Heydari, Vahid Mashayekhi Goyonlo, Mohammadali Kerachian, Josefine Persson, Hasan Rahimi-Tamandegani, Reza Erfanian Salim, Sima Rafati and 1 more

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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Non-coding RNAs as emerging players inFrontiers in cellular and infection microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shima Hadifar *Department of Immunotherapy and Leishmania Vaccine Research, Pasteur Institute of Iran, Tehran, Iran.
Nasrin Masoudzadeh *Department of Immunotherapy and Leishmania Vaccine Research, Pasteur Institute of Iran, Tehran, Iran.
Björn AnderssonBioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Hossein HeydariDepartment of Immunotherapy and Leishmania Vaccine Research, Pasteur Institute of Iran, Tehran, Iran.
Vahid Mashayekhi GoyonloCutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammadali KerachianCutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Josefine PerssonDepartment of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Hasan Rahimi-TamandeganiMedical Biotechnology Department, Pasteur Institute of Iran, Tehran, Iran.
Reza Erfanian SalimNoor Eye Hospital, Tehran, Iran.
Sima RafatiDepartment of Immunotherapy and Leishmania Vaccine Research, Pasteur Institute of Iran, Tehran, Iran.
Ali M HarandiDepartment of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cutaneous leishmaniasis (CL), caused by Methods: Herein, we used our previous RNA sequencing data (GSE216638) to investigate the profile of lncRNAs in the skin lesions of Results: We found substantial involvement of lncRNAs in the CL patient dataset. Using the WGCNA method, we classified all included genes into seven modules, with a module (turquoise) being significantly correlated with the studied clinical traits and identified as the key module. This module was mainly involved in the "interferon gamma signaling" and "cytokine signaling" pathways. We highlighted several lncRNAs and their co-expressed mRNA pairs, like SIRPG-AS1, IL21R-AS1, IL24, and TLDC2, as hub genes of the key module. Quantitative RT-PCR validated the expression of several genes in the lesions of an independent cohort of Conclusions: These findings enhance our understanding of the human skin response to

Indexed as

Gene Expression ProfilingLeishmaniasis, CutaneousLeishmania tropicaRNA, Long NoncodingRNA, MessengerGene Regulatory NetworksHumansTranscriptomeRNA, Long NoncodingRNA, Messengerco-expression networkcutaneous leishmaniasisLeishmania tropicalncRNAstranscriptomicsWGCNA

Identifiers

PMID39639867
PMCPMC11617529

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.