ArticleHeliyon2024
Fabrication and characterization of reinforced glass ionomer cement by zinc oxide and hydroxyapatite nanoparticles.
Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Controlled Intramedullary Pressure Fluctuations Enhanced Periosteal and Endosteal Bone Formation in Young, but Not Old, Fischer-344 Rats.Biomimetics (Basel, Switzerland) · 2026Article
- Effect of Knee Joint Meniscus Tears on Joint Cartilage Contact and Pressure with Finite Element Analysis.Biomedicines · 2026Article
- Bioactive restorative materials in dentistry: a comprehensive review of mechanisms, clinical applications, and future directions.Odontology · 2026Review
- Design Features of a Titanium Mesh for Guided Bone Regeneration and In Vivo Testing in Vitamin D3 Deficiency Condition.Biomimetics (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study shows the enhancement of glass ionomer cement (GIC) by incorporating hydroxyapatite (HA) and zinc oxide (ZnO) nanoparticles to improve its mechanical strength, biological activity, and antibacterial properties. GC is widely used in dental and orthopedic applications due to its bioactivity and biocompatibility, but it suffers from weak antibacterial properties and limited load-bearing capacity. HA, a calcium phosphate compound similar to natural bone, and ZnO, known for its antibacterial and bone-regenerative properties, were integrated into GIC to address these limitations. The modified GC exhibited improved compressive strength and bioactivity, particularly with the addition of 4 wt% ZnO nanoparticles, which showed the highest increase in mechanical performance while maintaining cytocompatibility. However, the fluoride release was reduced, indicating an exchange between enhanced mechanical properties and fluoride ion release. Antibacterial efficacy was assessed using well diffusion, MIC, and MBC tests, confirming that the modified GC has significant potential in dental and orthopedic applications. Future research should focus on the long-term effects of Zn
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.