Evidence map›Paper›PMID 39640921›Full record

ReviewRegenerative therapy2024

Insight of the interrelationship and association mechanism between periodontitis and diabetes mellitus.

Yongqiang Yang, Xia Sun, Yucheng Yang, Yingchun Qie

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Regenerative therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yongqiang YangStomatology Department, Yidu Central Hospital of Weifang, Weifang Medical University, No. 5168, Jiangjunshan Road, Qingzhou, Shandong Province, 262500, PR China.
Xia SunStomatology Department, Yidu Central Hospital of Weifang, Weifang Medical University, No. 5168, Jiangjunshan Road, Qingzhou, Shandong Province, 262500, PR China.
Yucheng YangStomatology Department, Yidu Central Hospital of Weifang, Weifang Medical University, No. 5168, Jiangjunshan Road, Qingzhou, Shandong Province, 262500, PR China.
Yingchun QieStomatology Department, Zibo First Hospital, Zibo, Shandong Province, 255200, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontitis and diabetes mellitus are two prevalent chronic diseases that have been recognized to exhibit a bidirectional relationship. Individuals with diabetes are more susceptible to periodontitis, and conversely, periodontitis can exacerbate glycemic control in diabetic patients. The underlying mechanisms of this interrelationship involve complex pathways, including inflammatory responses, altered immune functions, and microbial dysbiosis. The mechanistic insights into the interrelationship between periodontitis and diabetes mellitus revolve around the role of inflammation as a common link between the two diseases. Inflammatory mediators such as cytokines, chemokines, and prostaglandins play a crucial role in the pathogenesis and progression of the diseases. The dysregulation of the immune response in diabetes can exacerbate the inflammatory response in periodontitis, leading to increased tissue destruction and bone resorption. The chronic inflammation in periodontitis can contribute to insulin resistance and impaired glycemic control in diabetic patients. Future directions in research aim to further elucidate the molecular mechanisms underlying the interrelationship between periodontitis and diabetes mellitus. Modulating the inflammatory response, restoring microbial balance, and improving glycemic control hold promise in managing both conditions simultaneously. Herein, we will provide an overview of the interrelationship of periodontitis and diabetes mellitus, and retrospect the underlying mechanisms, which may inspire investigators with further research directions.

Indexed as

Alveolar bone resorptionDiabetes mellitusMicrobial balancePeri-implant diseasePeriodontitis

Identifiers

PMID39640921
PMCPMC11617686

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.