Evidence map›Paper›PMID 39642944›Full record

ArticleJournal of clinical epidemiology2025

Cross-national statistical harmonization of the Center for Epidemiologic Studies Depression (CES-D) scale among older adults in China, England, India, Mexico, South Africa, and the United States.

Xuexin Yu, Richard N Jones, Lindsay C Kobayashi, Alden L Gross

Abstract read
In one paragraph

Article in Journal of clinical epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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  10. Cumulative loneliness and memory function among U.S. older adults: the role of depressive symptoms.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Article
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xuexin YuCenter for Social Epidemiology and Population Health, Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA; Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.
Richard N JonesDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, RI, USA.
Lindsay C KobayashiCenter for Social Epidemiology and Population Health, Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), Faculty of Health Sciences, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.
Alden L GrossDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Center on Aging and Health, Johns Hopkins University, Baltimore, MD, USA. Electronic address: agross14@jhu.edu.

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
Project-001R01AG017644 · NIA · UNIVERSITY OF LONDON INST OF NEUROLOGY · PI Andrew Steptoe · 2000 to 2026
$56.2M
Integrting Information About Aging SurveysR01AG030153 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Sara Adar, Alden L. Gross · 2007 to 2026
$41.7M
Leveraging a natural experiment to estimate the causal impact of blood sugar on dementia and cognition in IndiaR01AG051125 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Jinkook Lee · 2015 to 2026
$26.8M
The Mexican Health and Aging Study - IIR01AG018016 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Rebeca Wong · 1999 to 2026
$22.6M
Health and Retirement Study: Harmonized Cognitive Assessment Protocol (HCAP)U01AG058499 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LANGA, KENNETH M · 2018 to 2023
$8.3M
Socioeconomic, Cardiovascular, and Psychosocial Sources of Cross-National Variation in Cognitive Health Among Older AdultsR01AG070953 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alden L. Gross, Lindsay C Kobayashi · 2021 to 2026
$4.6M
Cognitive Function, Alzheimer's Disease and Related Disorders in the HAALSI CohortR01AG054066 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI BERKMAN, LISA F · 2018 to 2022
$4.6M
Harmonized Cognitive and Dementia Assessment in ChinaR01AG053228 · NIA · PEKING UNIVERSITY · PI HUANG, YUEQIN, STRAUSS, JOHN A · 2016 to 2019
$1.7M
Research Network for the Harmonized Cognitive Assessment Protocol (HCAP)R24AG065182 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LANGA, KENNETH M, WEIR, DAVID R. · 2019 to 2021
$1.2M
MHAS Cognitive Aging Ancillary Study Administrative SupplementR01AG051158 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WONG, REBECA · 2015 to 2017
$1.1M
NIA NIH HHS R01 AG017644NIA NIH HHS R01 AG018016NIA NIH HHS R01 AG030153NIA NIH HHS R01 AG051125NIA NIH HHS R01 AG051158NIA NIH HHS R01 AG053228NIA NIH HHS R01 AG054066NIA NIH HHS R01 AG070953NIA NIH HHS R24 AG065182NIA NIH HHS U01 AG009740NIA NIH HHS U01 AG058499
6 · The paper itself

Abstract

objectivesWe examined differential item functioning (DIF) of the Center for Epidemiologic Studies Depression Scale (CES-D) items by country and statistically harmonized common cross-national factor scores for the CES-D to aid further cross-national research. STUDY DESIGN AND

settingData were from Harmonized Cognitive Assessment Protocol (HCAP) studies in China (N = 9639), England (N = 1262), India (N = 4048), Mexico (N = 1918), South Africa (N = 631), and the United States (N = 3321). Multiple indicators, multiple causes models were estimated to test DIF in the CES-D items by country. DIF items were defined as having an odds ratio (OR) outside the range of 0.75-1.25 in multiple indicators, multiple causes models. We evaluated DIF impact and identified salient DIF by examining whether the difference between DIF-adjusted factor scores and non-DIF-adjusted factor scores exceeded a threshold of 0.30 standard deviation (SD) units. Confirmatory factor analysis was used to create DIF-adjusted, cross-nationally harmonized CES-D factor scores.

resultsControlling for underlying depressive symptoms, HCAP participants in India had higher odds of reporting being not hopeful about future (OR = 1.38, 95% confidence interval [CI]: 1.34-1.42), not enjoying life (OR = 1.43, 95% CI: 1.38-1.48), and being unhappy (OR = 1.29, 95% CI: 1.25-1.34), compared to HCAP participants in the United States. These identified DIF items artificially increased mean harmonized CES-D factor scores by 0.48 SD units in the India HCAP, with over 50% of the factor scores increased by over 0.30 SD units, indicating salient DIF in the India HCAP.

conclusionOur findings demonstrate cross-national heterogeneity in the expression of depressive symptoms. We provide DIF-adjusted CES-D factor scores to improve the quality of cross-national comparisons in aging research.

Indexed as

DepressionPsychiatric Status Rating ScalesAgedAged, 80 and overChinaCross-Cultural ComparisonEnglandFactor Analysis, StatisticalFemaleHumansIndiaMaleMexicoMiddle AgedSouth AfricaUnited StatesAgingCenter for Epidemiologic Studies Depression Scale (CES-D)Cross-national comparisonItem response theoryMultiple indicator multiple cause modelStatistical harmonization

Identifiers

PMID39642944
PMCPMC12509702

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.