Evidence map›Paper›PMID 39645589›Full record

Trial reportCancer2025

Efficacy of a couple-based intervention addressing sexual concerns for breast cancer survivors: Results of a randomized controlled trial.

Jennifer Barsky Reese, Stephen J Lepore, Kristen A Sorice, Lauren A Zimmaro, Jill Hasler, Elizabeth Handorf, Mary B Daly, Alexandra K Zaleta, Kelly Westbrook, Laura S Porter

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jennifer Barsky ReeseDepartment of Social and Behavioral Sciences, College of Public Health, Temple University, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-9341-2407
Stephen J LeporeDepartment of Social and Behavioral Sciences, College of Public Health, Temple University, Philadelphia, Pennsylvania, USA.
Kristen A SoriceCancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
Lauren A ZimmaroDivision of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.
Jill HaslerDepartment of Biostatistics and Bioinformatics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
Elizabeth HandorfDepartment of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, New Jersey, USA.
Mary B DalyDepartment of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
Alexandra K ZaletaDepartment of Research, CancerCare, New York, New York, USA.ORCID https://orcid.org/0000-0002-8589-4722
Kelly WestbrookDepartment of Medicine-Oncology, Duke University Medical Center, Durham, North Carolina, USA.
Laura S PorterDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, USA.ORCID https://orcid.org/0000-0002-2962-2378

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Eric Andrew Ross · 1985 to 2026
$138.8M
TRAINING PROGRAM IN CANCER RESEARCHT32CA009035 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI CHERNOFF, JONATHAN · 1985 to 2020
$10.5M
Addressing Sexual Concerns in Breast Cancer Survivors: RCT of a Novel Couple-Based InterventionR01CA222124 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI REESE, JENNIFER BARSKY · 2018 to 2022
$3.0M
Addressing Colorectal Cancer-Related Distress: Developing and Evaluating a Couple-Based Mindfulness InterventionK08CA267313 · NCI · UNIVERSITY OF COLORADO DENVER · PI Lauren A. Zimmaro · 2022 to 2026
$847k
NCI NIH HHS K08 CA267313NCI NIH HHS P30 CA006927NCI NIH HHS P30CA006927NCI NIH HHS R01 CA222124NCI NIH HHS R01CA222124NCI NIH HHS T32 CA009035NCI NIH HHS T32-CA-009035
6 · The paper itself

Abstract

backgroundSexual concerns are common and problematic for breast cancer survivors. Partner and relationship factors often play a key role in determining survivors' sexual adjustment, making it likely that couple-based interventions that integrate survivors' partners could be especially promising for addressing survivors' sexual concerns. Yet few such interventions have been tested. The objective of this study was to evaluate the efficacy of the Intimacy Enhancement (IE) intervention, a four-session, couple-based intervention addressing breast cancer survivors' sexual concerns by telephone in a randomized controlled trial.

methodsFemale posttreatment breast cancer survivors reporting sexual concerns and their intimate partners (N = 120 couples; 240 participants) were randomized either to the IE intervention or to Living Healthy Together (LHT), an active control intervention of equivalent length. Outcomes (measured at baseline, postintervention, and at 3 and 6 months postintervention) included breast cancer survivors' sexual function (primary), partners' sexual function (secondary), and survivors' and partners' psychosocial and relationship outcomes (secondary). Mixed linear regression models examined intervention effects on outcomes at all follow-ups.

resultsModel-based estimates of intervention effects showed greater improvements in survivors' overall sexual function, sexual satisfaction, arousal, lubrication, and orgasm at postintervention (p < .05). Effects on survivors' 3-month and 6-month sexual functioning or other secondary outcomes were minimal. Most couples completed all IE sessions (97%) and LHT (92%), and satisfaction ratings were high.

conclusionsCompared with an active control intervention, the IE intervention had significant short-term benefits for survivors' sexual function. Efforts may be needed to increase the longevity of the positive effects, such as more frequent or adjunctive treatments.

Indexed as

Breast NeoplasmsCancer SurvivorsAdultAgedFemaleHumansMaleMiddle AgedQuality of LifeSexual BehaviorSexual Dysfunction, PhysiologicalSexual Partnersbreast cancerintimacyrandomized controlled trialsexual dysfunctiontelephone‐based

Identifiers

PMID39645589
PMCPMC11696781

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.