Evidence map›Paper›PMID 39649446›Full record

ArticleInterface focus2024

Inferring

Juan Diego Toscano, Chenxi Wu, Antonio Ladrón-de-Guevara, Ting Du, Maiken Nedergaard, Douglas H Kelley, George Em Karniadakis, Kimberly A S Boster

Abstract read
In one paragraph

Article in Interface focus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. KKANs: Ku̇rková-Kolmogorov-Arnold networks and their learning dynamics.Neural networks : the official journal of the International Neural Network Society · 2025
    Article
  6. Article
  7. MR-AIV revealsbioRxiv : the preprint server for biology · 2025
    Article
  8. From PINNs to PIKANs: recent advances in physics-informed machine learning.Machine learning for computational science and engineering · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. The pulsing brain: part I.Interface focus · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Juan Diego ToscanoDivision of Applied Mathematics, Brown University, Providence, RI 02912, USA.
Chenxi WuSchool of Engineering, Brown University, Providence, RI 02912, USA.
Antonio Ladrón-de-GuevaraCenter for Translational Neuromedicine and Department of Neuroscience, University of Rochester Medical Center, Rochester, NY 14627, USA.ORCID https://orcid.org/0000-0003-1093-2509
Ting DuCenter for Translational Neuromedicine and Department of Neuroscience, University of Rochester Medical Center, Rochester, NY 14627, USA.
Maiken NedergaardCenter for Translational Neuromedicine and Department of Neuroscience, University of Rochester Medical Center, Rochester, NY 14627, USA.
Douglas H KelleyDepartment of Mechanical Engineering, University of Rochester, Rochester, NY 14627, USA.ORCID https://orcid.org/0000-0001-9658-2954
George Em KarniadakisDivision of Applied Mathematics, Brown University, Providence, RI 02912, USA.ORCID https://orcid.org/0000-0002-9713-7120
Kimberly A S BosterDivision of Applied Mathematics, Brown University, Providence, RI 02912, USA.ORCID https://orcid.org/0000-0001-5178-128X

Funding

Viral Tool Development Core: Visualization and manipulation of brain fluid dynamics by recombinant viral vectorsU19NS128613 · NINDS · UNIVERSITY OF ROCHESTER · PI Hajime Hirase · 2022 to 2026
$13.6M
CRCNS: Waste-clearance flows in the brain measured using physics-informed neural networkR01AT012312 · NCCIH · UNIVERSITY OF ROCHESTER · PI Douglas H Kelley · 2022 to 2026
$1.6M
NCCIH NIH HHS R01 AT012312NINDS NIH HHS U19 NS128613
6 · The paper itself

Abstract

Cerebrospinal fluid (CSF) flow is crucial for clearing metabolic waste from the brain, a process whose dysregulation is linked to neurodegenerative diseases like Alzheimer's. Traditional approaches like particle tracking velocimetry (PTV) are limited by their reliance on single-plane two-dimensional measurements, which fail to capture the complex dynamics of CSF flow fully. To overcome these limitations, we employ artificial intelligence velocimetry (AIV) to reconstruct three-dimensional velocities, infer pressure and wall shear stress and quantify flow rates. Given the experimental nature of the data and inherent variability in biological systems, robust uncertainty quantification (UQ) is essential. Towards this end, we have modified the baseline AIV architecture to address aleatoric uncertainty caused by noisy experimental data, enhancing our measurement refinement capabilities. We also implement UQ for the model and epistemic uncertainties arising from the governing equations and network representation. Towards this end, we test multiple governing laws, representation models and initializations. Our approach not only advances the accuracy of CSF flow quantification but also can be adapted to other applications that use physics-informed machine learning to reconstruct fields from experimental data, providing a versatile tool for inverse problems.

Indexed as

cerebrospinal fluiddata assimilationexperimental methodsphysics-informed machine learning

Identifiers

PMID39649446
PMCPMC11621842

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.