Evidence map›Paper›PMID 39649579›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Convergent molecular signatures across eating disorders and obsessive-compulsive disorder in the human brain.

Michael S Breen, Ran Tao, Andy Yang, Xuran Wang, Pardis Amini, Miguel Rodriguez de Los Santos, Anna C Brandtjen, Amy Deep-Soboslay, Walter H Kaye, Thomas M Hyde and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Michael S BreenSeaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-6739-939X
Ran TaoThe Lieber Institute for Brain Development, Baltimore, MD, USA.
Andy YangSeaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Xuran WangSeaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Pardis AminiSeaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Miguel Rodriguez de Los SantosSeaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Anna C BrandtjenThe Lieber Institute for Brain Development, Baltimore, MD, USA.
Amy Deep-SoboslayThe Lieber Institute for Brain Development, Baltimore, MD, USA.
Walter H KayeDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Thomas M HydeThe Lieber Institute for Brain Development, Baltimore, MD, USA.
Joel E KleinmanThe Lieber Institute for Brain Development, Baltimore, MD, USA.
Joseph D BuxbaumSeaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Dorothy E GriceSeaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Funding

1/2 Rare Genetic Variation and Risk for Obsessive Compulsive DisorderR01MH124679 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2022 to 2025
$2.3M
NIMH NIH HHS R01 MH124679
6 · The paper itself

Abstract

Eating disorders (ED) and obsessive-compulsive disorder (OCD) exhibit significant clinical and genetic overlap, yet their shared molecular mechanisms remain unclear. We conducted a transcriptomic investigation of the dorsolateral prefrontal cortex (DLPFC) and caudate from 86 controls, 57 ED, and 27 OCD cases. ED was associated with robust differentially expressed genes (DEGs): 102 DEGs the DLPFC and 222 in the caudate (FDR < 1%) and replicated in an independent cohort. For OCD, no DEGs reached significance; however, meta-analysis with extant data identified 57 DEGs in the caudate. High concordance in transcriptomic changes was observed between ED and OCD in both regions (DLPFC

Identifiers

PMID39649579
PMCPMC11623724

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.