ArticleFrontiers in neurology2024
Predictive value of low serum interleukin-33 levels in acute ischemic stroke outcomes.
Article in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- The Role of the IL-33/ST2 Axis in Nervous System Development and Diseases.Immunology and cell biology · 2026Review
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Human interleukin-33 (IL-33), a member of the IL-1 family, has been identified as a therapeutic target due to its role as a proinflammatory mediator in various diseases. This study aims to evaluate the prognostic value of serum IL-33 levels in patients admitted with their first-ever acute ischemic stroke. Methods: This single-center, prospective, observational study included 216 patients with acute ischemic stroke. Serum IL-33 levels were measured at hospital admission to assess their predictive value for functional outcomes and mortality within 3 months. IL-33 levels were dichotomized at the median into two groups: the reduced group (IL-33 ≤ median) and the normal group (IL-33 > median). Results: The median age of the 216 patients was 66 years (interquartile range [IQR], 56-75), with 132 (61.6%) being women. IL-33 serum levels were inversely correlated with stroke severity, as measured by the National Institutes of Health Stroke Scale (NIHSS) score and lesion size. Patients in the reduced IL-33 group had a higher rate of unfavorable outcomes (55.6% vs. 18.5%; absolute difference, 29.2% [95% confidence interval (CI), 24.5% to 34.4%]; odds ratio (OR), 3.19 [95% CI, 1.72 to 5.91]) and mortality (24.1% vs. 3.7%; absolute difference, 15.8% [95% CI, 13.1% to 18.3%]; OR, 4.12 [95% CI, 1.38 to 12.31]) compared to the normal group. Furthermore, IL-33 levels enhanced the prognostic accuracy of the NIHSS for predicting functional outcomes (combined area under the curve [AUC], 0.84; 95% CI, 0.79-0.84; Conclusion: This study demonstrates that lower IL-33 levels are associated with increased stroke severity and poorer prognosis. These findings suggest that IL-33 may serve as a valuable biomarker for predicting poor outcomes following acute ischemic stroke.
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