Evidence map›Paper›PMID 39651064›Full record

ArticleBlood cell therapy2024

Serum 5-S-cysteinyldopa as a predictive biomarker for stem cell transplantation-related complications in children and young adults.

Yukayo Terashita, Akihiro Iguchi, Minako Sugiyama, Yuko Cho, Houman Goudarzi, Isao Yokota, Atsushi Manabe

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In one paragraph

Article in Blood cell therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yukayo TerashitaDepartment of Pediatrics, Graduate School of Medicine, Hokkaido University, Japan.
Akihiro IguchiDepartment of Pediatrics, Graduate School of Medicine, Hokkaido University, Japan.
Minako SugiyamaDepartment of Pediatrics, Graduate School of Medicine, Hokkaido University, Japan.
Yuko ChoDepartment of Pediatrics, Graduate School of Medicine, Hokkaido University, Japan.
Houman GoudarziDepartment of Respiratory Medicine, Graduate School of Medicine, Hokkaido University, Japan.
Isao YokotaDepartment of Biostatistics, Graduate School of Medicine, Hokkaido University, Japan.
Atsushi ManabeDepartment of Pediatrics, Graduate School of Medicine, Hokkaido University, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diffuse hyperpigmentation is common in patients who undergo chemotherapy or stem cell transplantation (SCT). However, only a few studies have reported the relation between skin reactions and SCT-related complications. Serum 5-S-cysteinyldopa (5SCD), a pheomelanin precursor, is elevated in individuals with hyperpigmentation. Here, we serially examined 5SCD levels during SCT to determine their association with SCT-related complications. We prospectively analyzed serum 5SCD levels in 41 patients (median age: 7.9 years; range: 0-22 years) who underwent SCT (allogeneic in 34 patients and autologous in 7 patients). The serum level of 5SCD increased on day 0, remained high on day 5, and gradually decreased to baseline levels on day 40 after SCT. An increase in 5SCD levels on day 0 was associated with the presence of viral reactivation (odds ratio [OR]: 3.32; 95% confidence interval [CI] 1.07-10.21,

Indexed as

5-S-cysteinyldopabiomarkerhyperpigmentationstem cell transplantation

Identifiers

PMID39651064
PMCPMC11620987

What Socratic holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.