Evidence map›Paper›PMID 39653378›Full record

ArticleJournal of the American Chemical Society2024

Site-Specific Glyco-Tagging of Native Proteins for the Development of Biologicals.

Ana Gimeno, Anna M Ehlers, Sandra Delgado, Jan-Willem H Langenbach, Leendert J van den Bos, John A W Kruijtzer, Bruno G A Guigas, Geert-Jan Boons

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ana GimenoChemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, CG 3584, The Netherlands.ORCID 0000-0001-9668-2605
Anna M EhlersChemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, CG 3584, The Netherlands.
Sandra DelgadoCIC bioGUNE, Basque Research & Technology Alliance (BRTA), Bizkaia Technology Park, Building 800, Derio 48160, Bizkaia Spain.
Jan-Willem H LangenbachChemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, CG 3584, The Netherlands.
Leendert J van den BosEnzyTag BV, Daelderweg 9, Nuth, HK NL-6361, The Netherlands.
John A W KruijtzerChemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, CG 3584, The Netherlands.
Bruno G A GuigasLeiden University Center of Infectious Diseases, Leiden University Medical Center, Leiden, ZA 2333, The Netherlands.
Geert-Jan BoonsChemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, CG 3584, The Netherlands.ORCID 0000-0003-3111-5954

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glycosylation is an attractive approach to enhance biological properties of pharmaceutical proteins; however, the precise installation of glycans for structure-function studies remains challenging. Here, we describe a chemoenzymatic methodology for glyco-tagging of proteins by peptidoligase catalyzed modification of the

Indexed as

GlycopeptidesGlycosylationHumansPolysaccharidesGlycopeptidesPolysaccharides

Identifiers

PMID39653378
PMCPMC11664507

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.