ArticleEuropean radiology2025
MR elastography-based detection of impaired skull-brain mechanical decoupling performance in response to repetitive head impacts.
Article in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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- Multiecho Fat-Water Spiral MR Elastography With Distributed Encoding for Simultaneously Imaging Brain and Skull Displacement.Magnetic resonance in medicine · 2026Article
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Abstract
objectiveTo evaluate MR elastography (MRE)-assessed biomarkers for detecting changes in skull-brain mechanical decoupling performance induced by repetitive head impacts (RHIs).
methodsThis prospective single-center study enrolled 80 asymptomatic participants (2017-2023) divided into three groups: no exposure (RHI(-)), low-impact (low RHI(+)), and high-impact (high RHI(+)). Four MRE-based parameters were evaluated to analyze the skull-brain decoupling performance: brain-to-skull rotational transmission ratio (Rtr), cortical shear strain (normalized OSS (octahedral shear strain)), cortical volumetric strain (normalized ONS (octahedral normal strain)), and the OSS-to-ONS ratio. Confounding factors (age/skull-brain distance, sex) were controlled with a linear regression model. One-way ANOVA with Tukey's post-hoc test was used for group comparisons.
resultsThe high RHI(+) showed a significantly increased adjusted Rtr compared to the RHI(-) and low RHI(+) (p < 0.001). Higher adjusted OSS-to-ONS ratios were found in the high RHI(+) in the frontal (q < 0.05), parietal (q < 0.001), and occipital (q < 0.05) lobes compared to the RHI(-), and in all regions compared to the low RHI(+) (q < 0.05). The high RHI(+) exhibited lower adjusted normalized ONS and OSS in the temporal lobe (q < 0.05) compared to the low RHI(+). These findings suggest that recent and prolonged RHI exposures may impair the skull-brain decoupling performance, affecting the capacity of the interface to isolate the brain by dampening skull-to-brain motion transmission and modulating brain surface deformation.
conclusionThis study reveals evidence of impaired decoupling function at the skull-brain interface resulting from RHI exposure and demonstrates MRE-based biomarkers for early detection of this impairment. KEY POINTS: Question The skull-brain interface is crucial for brain protection under impact, but its early mechanical responses to repetitive head impacts (RHIs) remain largely unknown. Findings Mechanical changes (more rotation and a shift in shear relative to volumetric strain) across the skull-brain interface were observed in participants under high RHI exposure. Clinical relevance Our study developed MR elastography (MRE)-based measurements to detect changes in the skull-brain interface caused by RHI, suggesting that MRE holds promise for noninvasively quantifying cumulative injury and potential future clinical interventions for individuals with high RHI exposure.
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