Evidence mapPaperPMID 39654803Full record

ArticleInternational journal of nanomedicine2024

RNA-Seq Reveals the Mechanism of Pyroptosis Induced by Oxygen-Enriched IR780 Nanobubbles-Mediated Sono-Photodynamic Therapy.

Xiang He, Yuhang Tian, Jialin Dong, Yanchi Yuan, Shijie Zhang, Hui Jing

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiang He *Department of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, People's Republic of China.ORCID 0000-0002-6506-799X
Yuhang Tian *Department of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, People's Republic of China.
Jialin DongDepartment of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, People's Republic of China.
Yanchi YuanDepartment of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, People's Republic of China.
Shijie ZhangDepartment of Radiation Oncology, Harbin Medical University Cancer Hospital, Harbin, People's Republic of China.
Hui JingDepartment of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, People's Republic of China.ORCID 0000-0002-6615-709X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sono-photodynamic therapy (SPDT), the combination of sonodynamic therapy (SDT) and photodynamic therapy (PDT), is a promising tumor treatment method. However, the hypoxic tumor microenvironment greatly compromises the efficacy of SPDT. Pyroptosis, a new type of programmed cell death, is mainly induced by some chemotherapeutic drugs in the current research, and rarely by SPDT. RNA sequencing (RNA-seq) is a high-throughput sequencing technique that comprehensively profiles the transcriptome, revealing the full spectrum of RNA molecules in a cell. Here, we constructed IR780@O Methods: Thin-film hydration and mechanical vibration method were utilized to synthesize IR780@O Results: IR780@O Conclusion: The IR780@O

Indexed as

IndolesOxygenPhotochemotherapyPyroptosisTriple Negative Breast NeoplasmsUltrasonic TherapyAnimalsCell Line, TumorFemaleHumansPhotosensitizing AgentsReactive Oxygen SpeciesRNA-SeqTumor Microenvironment2-(2-(2-chloro-3-((1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propylindoliumIndolesOxygenPhotosensitizing AgentsReactive Oxygen Specieshypoxia reliefpyroptosisRNA-seqsono-photodynamic therapytriple negative breast cancer

Identifiers

PMID39654803
PMCPMC11625641

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.