Evidence map›Paper›PMID 39655234›Full record

ArticleFrontiers in medicine2024

Vitamin D deficiency and duration of COVID-19 symptoms in UK healthcare workers.

Karan R Chadda, Sophie A Roberts, Sebastian T Lugg, Aduragbemi A Faniyi, Sian E Faustini, Craig Webster, Joanne E Duffy, Martin Hewison, Adrian Shields, Alex G Richter and 3 more

Abstract read
In one paragraph

Article in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Karan R Chadda *Acute Care Research Group, Department of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom.
Sophie A Roberts *Acute Care Research Group, Department of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom.
Sebastian T LuggAcute Care Research Group, Department of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom.
Aduragbemi A FaniyiAcute Care Research Group, Department of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom.
Sian E FaustiniClinical Immunology Service, Department of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Craig WebsterUniversity Hospitals Birmingham National Health Service Foundation Trust, Birmingham, United Kingdom.
Joanne E DuffyUniversity Hospitals Birmingham National Health Service Foundation Trust, Birmingham, United Kingdom.
Martin HewisonDepartment of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.
Adrian ShieldsClinical Immunology Service, Department of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Alex G RichterClinical Immunology Service, Department of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.
Dhruv ParekhAcute Care Research Group, Department of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom.
Aaron ScottAcute Care Research Group, Department of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom.
David R ThickettAcute Care Research Group, Department of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Objectives: Vitamin D has a role in the innate immunity against pathogens and is also involved in mechanisms for reducing inflammation. VD deficiency (VDD) may increase COVID-19 infection susceptibility, however research is limited on the association between VDD and COVID-19 symptom prevalence and duration. The study aimed to determine whether VDD is a risk factor for the presence and extended duration of COVID-19 symptoms. Methods: Data was analyzed from NHS healthcare workers who isolated due to COVID-19 symptoms as a part of the COVID-19 convalescent immunity study between 12th to 22nd May 2020. Participants self-reported the presence and duration of viral symptoms. Anti-SARS-CoV-2 antibodies and vitamin D (25(OH)D Results: Of the 392 participants, 15.6% ( Conclusion: VDD is a significant independent risk factor for extended durations of body aches and fatigue in healthcare workers who isolated for COVID-19 viral symptoms. Vitamin D supplementation may reduce symptom duration and is thus an area for future research.

Indexed as

COVID-19healthcare workerslong COVIDviral symptomsvitamin D

Identifiers

PMID39655234
PMCPMC11625565

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.