ArticleMolecular biology and evolution2024
Phylogenetic Analysis of 590 Species Reveals Distinct Evolutionary Patterns of Intron-Exon Gene Structures Across Eukaryotic Lineages.
Article in Molecular biology and evolution, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The shortest animal introns: insights from parasitic cnidarians.Molecular biology and evolution · 2026Article
- The KeyPlants (Basel, Switzerland) · 2026Article
- Genome-Wide Characterization and Expression Analysis of Heat Shock Transcription Factors in Two Cultivars of Rice (International journal of molecular sciences · 2026Article
- Genome-Wide Identification of the CaPlants (Basel, Switzerland) · 2026Article
- Pan-Genomic Analysis and Functional Characterization of thePlants (Basel, Switzerland) · 2026Article
- Beyond gene length: Exon-intron architecture and isoform potential in the evolution of eukaryotic complexity.bioRxiv : the preprint server for biology · 2026Article
- Comprehensive genomic analysis of BAHD gene family: expression patterns during development and stress responses in pecan (Carya illinoinensis).BMC genomics · 2026Article
- Evolutionary diversity of sphingolipid metabolism proteins in fungi.IMA fungus · 2026Article
- Genome-wide characterization of NHX gene family in Medicago sativa under abiotic stress.BMC plant biology · 2025Article
- Tracing the stepwise Darwinian evolution of a plant halogenase.Science advances · 2025Article
- Systematic revelation and meditation on the significance of long exons using representative eukaryotic genomes.BMC genomics · 2025Article
- Direct repeats found in the vicinity of intron splice sites.Die Naturwissenschaften · 2025Article
- Comprehensively characterize the soybean CAM/CML gene family, as it provides resistance against both the soybean mosaic virus andFrontiers in plant science · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
Introns are highly prevalent in most eukaryotic genomes. Despite the accumulating evidence for benefits conferred by the possession of introns, their specific roles and functions, as well as the processes shaping their evolution, are still only partially understood. Here, we explore the evolution of the eukaryotic intron-exon gene structure by focusing on several key features such as the intron length, the number of introns, and the intron-to-exon length ratio in protein-coding genes. We utilize whole-genome data from 590 species covering the main eukaryotic taxonomic groups and analyze them within a statistical phylogenetic framework. We found that the basic gene structure differs markedly among the main eukaryotic groups, with animals, and particularly chordates, displaying intron-rich genes, compared with plants and fungi. Reconstruction of gene structure evolution suggests that these differences evolved prior to the divergence of the main phyla and have remained mostly conserved within groups. We revisit the previously reported association between the genome size and the mean intron length and report that this association differs considerably among phyla. Analyzing a large and diverse dataset of species with whole-genome information while applying advanced modeling techniques allowed us to obtain a global evolutionary perspective. Our findings may indicate that introns play different molecular and evolutionary roles in different organisms.
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