ArticleOpen biology2024
Thermal measurements support a role of the ABA/LANCL1-2 hormone/receptors system in thermogenesis.
Article in Open biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Role of Abscisic Acid in the Whole-Body Regulation of Glucose Uptake and Metabolism.Nutrients · 2024Review
- Thermal measurements support a role of the ABA/LANCL1-2 hormone/receptors system in thermogenesis.Open biology · 2024Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abscisic acid (ABA) is a conserved 'stress hormone' in unicellular organisms, plants and animals. In mammals, ABA and its receptors LANCL1 and LANCL2 stimulate insulin-independent cell glucose uptake and oxidative metabolism: overexpression of LANCL1/2 increases, and their silencing conversely reduces, mitochondrial number, respiration and proton gradient dissipation in muscle cells and in brown adipocytes. We hypothesized that the ABA/LANCL hormone/receptors system could be involved in thermogenesis. Heat production by LANCL1/2-overexpressing versus double-silenced cells was compared in rat H9c2 cardiomyocytes with two different methods: differential temperature measurements using sensitive thermistor probes and differential isothermal calorimetry. Overexpressing cells generate an approximately double amount of thermal power compared with double-silenced cells, and addition of ABA further doubles heat production in overexpressing cells. With the temperature probes, we find a timescale of approximately 4 min for thermogenesis to 'turn on' after nutrient addition. We provide direct measurements of increased heat production triggered by the ABA/LANCL hormone receptors system. Combined with previous work on oxphos decoupling, these results support the role of the ABA/LANCL hormone receptors system as a hitherto unknown regulator of cell thermogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.