Evidence map›Paper›PMID 39658487›Full record

ReviewTrends in parasitology2025

The type 2 immune response in gut homeostasis and parasite transmission in malaria.

Nora Céspedes, Renée M Tsolis, Adrian M Piliponsky, Shirley Luckhart

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in parasitology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nora CéspedesDepartment of Entomology, Plant Pathology and Nematology, University of Idaho, Moscow, ID, USA. Electronic address: nora@uidaho.edu.
Renée M TsolisDepartment of Medical Microbiology and Immunology, University of California-Davis, Davis, CA, USA.
Adrian M PiliponskyDepartment of Pediatrics and Department of Pathology, Seattle Children's Research Institute, Seattle, WA, USA.
Shirley LuckhartDepartment of Entomology, Plant Pathology and Nematology, University of Idaho, Moscow, ID, USA; Department of Biological Sciences, University of Idaho, Moscow, ID, USA.

Funding

Neutrophil-intrinsic role of SLC11A1/NRAMP1 in control of bacterial infectionR01AI149632 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TSOLIS, RENEE M · 2019 to 2023
$2.4M
Biogenic amines, malaria and manipulation of mosquito physiology and behavior.R01AI165481 · NIAID · UNIVERSITY OF IDAHO · PI LUCKHART, SHIRLEY, RIFFELL, JEFFREY A · 2022 to 2025
$2.2M
Malaria and allergic inflammatory changes to the gut barrierR01AI131609 · NIAID · UNIVERSITY OF IDAHO · PI LUCKHART, SHIRLEY · 2018 to 2021
$1.9M
NIAID NIH HHS R01 AI131609NIAID NIH HHS R01 AI149632NIAID NIH HHS R01 AI165481
6 · The paper itself

Abstract

Malaria predisposes to concomitant bacteremia, resulting in increased mortality risk. Previous studies indicated that malaria causes structural changes in the intestine, induces tolerogenic immune responses, inhibits neutrophil recruitment, suppresses innate synthesis of IFN-γ, dysregulates mast cells (MCs) and basophils, and induces Th2-type immune responses. These can reduce parasite control while increasing enteropathogenic dissemination. Moreover, there is growing evidence that Th2 immunity, while protecting the host from overwhelming inflammation, may also contribute to increased parasite transmission. This review explores the roles of the regulatory immune response in bacterial coinfections and parasite transmission in malaria.

Indexed as

HomeostasisMalariaAnimalsHumansTh2 Cellsbacteremiaimmunoregulatory responsemalariatransmissiontype 2 immunity

Identifiers

PMID39658487
PMCPMC12169618

What Socratic holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.