Evidence map›Paper›PMID 39659394›Full record

ArticleClinical parkinsonism & related disorders2024

Comparison of MIBG uptake in the major salivary glands between Lewy body disease and progressive supranuclear palsy.

Junya Ebina, Sunao Mizumura, Mari Shibukawa, Harumi Morioka, Junpei Nagasawa, Masaru Yanagihashi, Takehisa Hirayama, Nobutomo Ishii, Yukio Kobayashi, Akira Inaba and 2 more

Abstract read
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In one paragraph

Article in Clinical parkinsonism & related disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Junya EbinaDepartment of Neurology, Toho University Faculty of Medicine, Tokyo, Japan.
Sunao MizumuraDepartment of Radiology, Toho University Faculty of Medicine, Tokyo, Japan.
Mari ShibukawaDepartment of Neurology, Toho University Faculty of Medicine, Tokyo, Japan.
Harumi MoriokaDepartment of Neurology, Toho University Faculty of Medicine, Tokyo, Japan.
Junpei NagasawaDepartment of Neurology, Toho University Faculty of Medicine, Tokyo, Japan.
Masaru YanagihashiDepartment of Neurology, Toho University Faculty of Medicine, Tokyo, Japan.
Takehisa HirayamaDepartment of Neurology, Toho University Faculty of Medicine, Tokyo, Japan.
Nobutomo IshiiCentral Radiology Division, Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan.
Yukio KobayashiDepartment of Radiological Technology, Kanto Central Hospital, Tokyo, Japan.
Akira InabaDepartment of Neurology, Kanto Central Hospital, Tokyo, Japan.
Satoshi OrimoKamiyoga Setagaya Street Clinic, Tokyo, Japan.
Osamu KanoDepartment of Neurology, Toho University Faculty of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cardiac sympathetic denervation is specific to Lewy body disease (LBD). In Parkinson's disease (PD), sympathetic denervation in the major salivary glands (parotid glands [PG] and submandibular glands [SMG]) has been demonstrated by Methods: We recruited 81 patients with PD, 12 with DLB, 13 with PSP and 25 with control subjects. We evaluated MIBG uptake in the major salivary glands and heart using a quantitative semi-automatic method. We compared MIBG uptake between PD, DLB, and PSP patients and controls, and we evaluated disease sensitivity and specificity. We compared olfactory function with MIBG uptake between PD and PSP patients. Results: MIBG uptake in the PG and SMG in the delayed phase was significantly lower in PD and DLB patients than in PSP patients and controls. Conversely, MIBG uptake in the major salivary glands and heart was comparable between PD and DLB. Between LBD and non-LBD, MIBG uptake showed 56-100 % specificity in the PG, while it had 55.6-87.5 % sensitivity in the SMG. Between PD and PSP, MIBG uptake in the PG and SMG had higher disease specificity than olfactory function, while the sensitivity of SMG MIBG uptake was comparable to olfactory function. Conclusion: PD and DLB patients showed lower MIBG uptake in the major salivary glands than PSP patients, especially in the delayed phase. MIBG uptake in the major salivary glands may differentiate PD from hyposmic PSP.

Indexed as

Dementia with Lewy bodiesMajor salivary glandsMIBG scintigraphyParkinson’s diseaseProgressive supranuclear palsy

Identifiers

PMID39659394
PMCPMC11629250

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.