Evidence map›Paper›PMID 39659701›Full record

ReviewFrontiers in toxicology2024

AI and ML-based risk assessment of chemicals: predicting carcinogenic risk from chemical-induced genomic instability.

Ajay Vikram Singh, Preeti Bhardwaj, Peter Laux, Prachi Pradeep, Madleen Busse, Andreas Luch, Akihiko Hirose, Christopher J Osgood, Michael W Stacey

Abstract readReview
In one paragraph

Review in Frontiers in toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Development andACS omega · 2026
    Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Transforming beef quality through healthy breeding: a strategy to reduce carcinogenic compounds and enhance human health: a review.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Review
  17. Review
  18. Review
  19. Innovative nanoparticle strategies for treating oral cancers.Medical oncology (Northwood, London, England) · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ajay Vikram Singh *Department of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany.
Preeti Bhardwaj *Department of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany.
Peter Laux *Department of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany.
Prachi PradeepDepartment of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany.
Madleen BusseDepartment of Biological Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany.
Andreas LuchDepartment of Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany.
Akihiko HiroseChemicals Evaluation and Research Institute, Tokyo, Japan.
Christopher J OsgoodDepartment of Biological Sciences, Old Dominion University, Norfolk, VA, United States.
Michael W StaceyFrank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemical risk assessment plays a pivotal role in safeguarding public health and environmental safety by evaluating the potential hazards and risks associated with chemical exposures. In recent years, the convergence of artificial intelligence (AI), machine learning (ML), and omics technologies has revolutionized the field of chemical risk assessment, offering new insights into toxicity mechanisms, predictive modeling, and risk management strategies. This perspective review explores the synergistic potential of AI/ML and omics in deciphering clastogen-induced genomic instability for carcinogenic risk prediction. We provide an overview of key findings, challenges, and opportunities in integrating AI/ML and omics technologies for chemical risk assessment, highlighting successful applications and case studies across diverse sectors. From predicting genotoxicity and mutagenicity to elucidating molecular pathways underlying carcinogenesis, integrative approaches offer a comprehensive framework for understanding chemical exposures and mitigating associated health risks. Future perspectives for advancing chemical risk assessment and cancer prevention through data integration, advanced machine learning techniques, translational research, and policy implementation are discussed. By implementing the predictive capabilities of AI/ML and omics technologies, researchers and policymakers can enhance public health protection, inform regulatory decisions, and promote sustainable development for a healthier future.

Indexed as

artificial intelligence (AI)chemical risk assessmentclastogen-induced carcinogenesisgenomic instabilitymachine learning (ML)

Identifiers

PMID39659701
PMCPMC11628524

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.