Evidence map›Paper›PMID 39659726›Full record

ReviewBioactive materials2025

Engineering soft-hard tissue interfaces in dental and craniofacial system by spatially controlled bioactivities.

Hun Jin Jeong, Lan Anh P Hoang, Neeve Chen, Elen Zhu, Albert Wang, Bozhi Chen, Emma Y Wang, Christopher L Ricupero, Chang H Lee

Abstract readReview
In one paragraph

Review in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hun Jin JeongCollege of Dental Medicine, Columbia University Irving Medical Center, 630 W. 168 St. - VC12-212, New York, NY, 10032, USA.
Lan Anh P HoangCollege of Dental Medicine, Columbia University Irving Medical Center, 630 W. 168 St. - VC12-212, New York, NY, 10032, USA.
Neeve ChenCollege of Dental Medicine, Columbia University Irving Medical Center, 630 W. 168 St. - VC12-212, New York, NY, 10032, USA.
Elen ZhuCollege of Dental Medicine, Columbia University Irving Medical Center, 630 W. 168 St. - VC12-212, New York, NY, 10032, USA.
Albert WangCollege of Dental Medicine, Columbia University Irving Medical Center, 630 W. 168 St. - VC12-212, New York, NY, 10032, USA.
Bozhi ChenCollege of Dental Medicine, Columbia University Irving Medical Center, 630 W. 168 St. - VC12-212, New York, NY, 10032, USA.
Emma Y WangCollege of Dental Medicine, Columbia University Irving Medical Center, 630 W. 168 St. - VC12-212, New York, NY, 10032, USA.
Christopher L RicuperoCollege of Dental Medicine, Columbia University Irving Medical Center, 630 W. 168 St. - VC12-212, New York, NY, 10032, USA.
Chang H LeeCollege of Dental Medicine, Columbia University Irving Medical Center, 630 W. 168 St. - VC12-212, New York, NY, 10032, USA.

Funding

Bioactive Scaffold for TMJ Disc Regeneration by Endogenous Stem/Progenitor CellsR01DE029321 · NIDCR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEE, CHANG HUN · 2020 to 2024
$3.5M
NIDCR NIH HHS R01 DE029321
6 · The paper itself

Abstract

The interface between soft and hard tissues is constituted by a gradient change of cell types and matrix compositions that are optimally designed for proper load transmission and injury protection. In the musculoskeletal system, the soft-hard tissue interfaces at tendon-bone, ligament-bone, and meniscus-bone have been extensively researched as regenerative targets. Similarly, extensive research efforts have been made to guide the regeneration of multi-tissue complexes in periodontium. However, the other soft-hard tissue interfaces in the dental and craniofacial system have been somewhat neglected. This review discusses the clinical significance of developing regenerative strategies for soft-hard tissue interfaces in the dental and craniofacial system. It also discusses the research progress in the field focused on bioengineering approaches using 3D scaffolds equipped with spatially controlled bioactivities. The remaining challenges, future perspectives, and considerations for the clinical translation of bioactive scaffolds are also discussed.

Indexed as

Bioactive scaffoldMulti-tissue interfacePeriodontiumRegenerative engineeringTemporomandibular joint disordersTissue engineeringTissue regeneration

Identifiers

PMID39659726
PMCPMC11629151

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.