Evidence map›Paper›PMID 39659841›Full record

ArticleMaterials today. Bio2024

Nanoplatform for synergistic therapy constructed via the co-assembly of a reduction-responsive cholesterol-based block copolymer and a photothermal amphiphile.

Yue Lu, Tiantian Cai, Juanjuan Gao, Yangge Ren, Yi Ding, Shujing Liu, Linyuan Liu, Hao Huang, Haijie Wang, Chengji Wang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yue LuDepartment of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Nanchen Street 333, Shanghai, 200444, China.
Tiantian CaiDepartment of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Nanchen Street 333, Shanghai, 200444, China.
Juanjuan GaoDepartment of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Nanchen Street 333, Shanghai, 200444, China.
Yangge RenDepartment of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Nanchen Street 333, Shanghai, 200444, China.
Yi DingDepartment of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Nanchen Street 333, Shanghai, 200444, China.
Shujing LiuDepartment of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Nanchen Street 333, Shanghai, 200444, China.
Linyuan LiuDepartment of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Nanchen Street 333, Shanghai, 200444, China.
Hao HuangDepartment of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Nanchen Street 333, Shanghai, 200444, China.
Haijie WangShanghai Laboratory Animal Research Center, Jinke Street 3577, Shanghai, 201203, China.
Chengji WangShanghai Laboratory Animal Research Center, Jinke Street 3577, Shanghai, 201203, China.
Wei WangGeriatric Medicine Department, The Fifth Affiliated Hospital of Southern Medical University, Congcheng Street 566, Guangzhou, 510920, China.
Ruling ShenShanghai Laboratory Animal Research Center, Jinke Street 3577, Shanghai, 201203, China.
Bo ZhuDepartment of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Nanchen Street 333, Shanghai, 200444, China.
Lin JiaDepartment of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Nanchen Street 333, Shanghai, 200444, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The goal of combination cancer therapy, including chemo-phototherapy, is to achieve highly efficient antitumor effects while minimizing the adverse reactions associated with conventional chemotherapy. Nevertheless, enhancing the contribution of non-chemotherapeutic strategies in combination therapy is often challenging because this requires multiple active ingredients to be encapsulated in a single delivery system. However, most commonly used photothermal reagents are challenging to be loaded in large quantities and have poor biocompatibility. Herein, we developed photothermal co-micelles through a co-assembly strategy using a cholesterol-based liquid crystal block copolymer (LC-BCP) with disulfide bonds in the side chain of the LC blocks and a croconaine-based amphiphile (CBA) containing a cholesterol moiety. This approach allowed the CBA to be effectively embedded within LC-BCPs, serving as the functional component of the drug-loaded carrier. These co-micelles could encapsulate doxorubicin (DOX), showed tunable reduction-responsive drug release, and enabled near-infrared laser-triggered photothermal therapy as well as

Identifiers

PMID39659841
PMCPMC11629281

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.