Evidence map›Paper›PMID 39660496›Full record

ReviewRecent advances in drug delivery and formulation2025

Non-Ionic Surfactant Vesicles (Niosomes): Structure, Functions, Classification and its Advances in Enhanced Drug Delivery.

Pavan Kumar Padarthi, V Kalvimoorthi, Ranadheer Reddy Challa, Bhaskar Vallamkonda, Neelima Grandhe, Lakshman Kumar Dogiparthi, Rajaganapathy Kaliyaperumal

Abstract readReview
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In one paragraph

Review in Recent advances in drug delivery and formulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pavan Kumar PadarthiDepartment of Physiology and Pharmacology, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chowdavaram, Guntur, 522019, Andhra Pradesh, India.ORCID 0000-0003-1042-9532
V KalvimoorthiDepartment of Pharmaceutics, Aadhibhagawan College of Pharmacy, Randam, 604407, Tamil Nadu, India.ORCID 0009-0009-9488-7805
Ranadheer Reddy ChallaFormulation and Development, Quotient Sciences, Garnatvelly, USA.
Bhaskar VallamkondaDepartment of Pharmaceutical Science, School of Applied Sciences and Humanities, VIGNAN's Foundation for Science, Technology & Research, Vadlamudi, 522213, Andhra Pradesh, India.
Neelima GrandheDepartment of Pharmaceutical Analysis, Sri Venkateswara College of Pharmacy (Autonomous), Chittoor, Andhra Pradesh, India.ORCID 0000-0003-0298-8705
Lakshman Kumar DogiparthiDepartment of Pharmacognosy, Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra Pradesh, India.
Rajaganapathy KaliyaperumalDepartment of Pharmacology, Faculty of Pharmacy, Bharath Institute of Higher Education and Research, Selaiyur, Chennai, 600073, Tamil Nadu, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-ionic surfactant vesicles, commonly known as niosomes, have gained significant attention in the field of drug delivery because of their unique properties and advantages. Niosomes are self-assembled vesicles composed of non-ionic surfactants and cholesterol that can entrap both hydrophilic and hydrophobic drugs within their aqueous core or bilayer. This versatile drug delivery system offers improved stability, prolonged release profiles, reduced toxicity, and enhanced efficacy for a wide range of therapeutic agents. This comprehensive article delves into the structure, function, classification, and advances in niosomes for enhanced drug delivery. It explores various nonionic surfactants used for niosome formulation and discusses their impact on encapsulation efficiency and stability. Moreover, it highlights the application of niosomes in the delivery of small molecules, proteins, and plant-derived natural products. This article provides an overview of the different formulation methods employed for niosome preparation and discusses recent advancements that have expanded their potential applications in targeted drug delivery systems.

Indexed as

Drug Delivery SystemsLiposomesSurface-Active AgentsAnimalsCholesterolHumansHydrophobic and Hydrophilic InteractionsCholesterolLiposomesSurface-Active Agentsaqueous corebilayercholesterolhydrophilic drugshydrophobic drugs.Niosomesnon-ionic surfactants

Identifiers

PMID39660496

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.