Evidence map›Paper›PMID 39660822›Full record

ArticleeLife2024

Malaria parasites require a divergent heme oxygenase for apicoplast gene expression and biogenesis.

Amanda Mixon Blackwell, Yasaman Jami-Alahmadi, Armiyaw S Nasamu, Shota Kudo, Akinobu Senoo, Celine Slam, Kouhei Tsumoto, James A Wohlschlegel, Jose Manuel Martinez Caaveiro, Daniel E Goldberg and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Heme and immunity: The heme oxygenase dichotomy.Journal of inorganic biochemistry · 2025
    Review
  6. Article
  7. Identification of a divalent metal transporter required for cellular iron metabolism in malaria parasites.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Amanda Mixon BlackwellDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.ORCID https://orcid.org/0000-0002-7473-5822
Yasaman Jami-AlahmadiDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, United States.ORCID https://orcid.org/0000-0001-8289-2222
Armiyaw S NasamuDepartments of Medicine and Molecular Microbiology, Washington University School of Medicine, St. Louis, United States.
Shota KudoDepartment of Chemistry & Biotechnology, The University of Tokyo, Tokyo, Japan.
Akinobu SenooDepartment of Protein Drug Discovery, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Celine SlamDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.
Kouhei TsumotoDepartment of Chemistry & Biotechnology, The University of Tokyo, Tokyo, Japan.
James A WohlschlegelDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, United States.
Jose Manuel Martinez CaaveiroDepartment of Chemistry & Biotechnology, The University of Tokyo, Tokyo, Japan.
Daniel E GoldbergDepartments of Medicine and Molecular Microbiology, Washington University School of Medicine, St. Louis, United States.ORCID https://orcid.org/0000-0003-3529-8399
Paul A SigalaDepartment of Biochemistry, University of Utah School of Medicine, Salt Lake City, United States.ORCID https://orcid.org/0000-0002-3464-3042

Funding

RESEARCH TRAINING IN HEMATOLOGYT32DK007115 · NIDDK · UNIVERSITY OF UTAH · PI LEIBOLD, ELIZABETH ANN, PRCHAL, JOSEF T · 1986 to 2020
$8.4M
IRON REGULATION OF GENE EXPRESSTIONR01GM045201 · NIGMS · UNIVERSITY OF UTAH · PI LEIBOLD, ELIZABETH ANN · 1991 to 2013
$4.4M
Comparative Heme Metabolism in Divergent EukaryotesR35GM133764 · NIGMS · UNIVERSITY OF UTAH · PI SIGALA, PAUL A · 2019 to 2023
$2.1M
Iron in beta cell functionR01DK107712 · NIDDK · UNIVERSITY OF UTAH · PI LEIBOLD, ELIZABETH ANN · 2016 to 2019
$1.5M
Genomics Summer Research for Minorities: A Pathway to Promote Diversity in Science ResearchR25HG009886 · NHGRI · UNIVERSITY OF UTAH · PI YOST, H. JOSEPH · 2018 to 2022
$1.3M
Understanding Ubiquitin-dependent Regulation of Iron Metabolism using Mass SpectrometryR35GM153408 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI James Akira Wohlschlegel · 2024 to 2026
$1.2M
Genetic Analysis of Iron Homeostasis in C.ElegansR01DK068602 · NIDDK · UNIVERSITY OF UTAH · PI LEIBOLD, ELIZABETH ANN · 2006 to 2010
$1.2M
ROLE OF PFHO-1 IN P. FALCIPARUM INTRAERYTHROCYTIC DEVELOPMENTR21AI110712 · NIAID · WASHINGTON UNIVERSITY · PI GOLDBERG, DANIEL E. · 2014 to 2015
$408k
Burroughs Wellcome Fund 1011969National Institute of Allergy and Infectious Diseases R21AI110712NHGRI NIH HHS R25 HG009886NHGRI NIH HHS R25HG009886NIAID NIH HHS R21 AI110712NIDDK NIH HHS R01 DK068602NIDDK NIH HHS R01 DK107712NIDDK NIH HHS T32 DK007115NIDDK NIH HHS T32DK007115NIGMS NIH HHS R01 GM045201NIGMS NIH HHS R35 GM133764NIGMS NIH HHS R35GM133764NIGMS NIH HHS R35 GM153408NIGMS NIH HHS R35GM153408Pew Charitable Trusts 32099
6 · The paper itself

Abstract

Malaria parasites have evolved unusual metabolic adaptations that specialize them for growth within heme-rich human erythrocytes. During blood-stage infection,

Indexed as

ApicoplastsHeme Oxygenase (Decyclizing)Plasmodium falciparumProtozoan ProteinsCrystallography, X-RayGene Expression RegulationHemeHumansMalaria, FalciparumHemeHeme Oxygenase (Decyclizing)Protozoan Proteinsapicoplastbiochemistrychemical biologygene expressionheme oxygenaseinfectious diseasemalariamicrobiologyP. falciparumRNA

Identifiers

PMID39660822
PMCPMC11634067

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.