Evidence map›Paper›PMID 39661664›Full record

ArticleScience advances2024

Transcriptomic landscape of mammalian ventral pallidum at single-cell resolution.

Lite Yang, Lisa Z Fang, Michelle R Lynch, Chang S Xu, Hannah J Hahm, Yufen Zhang, Monique R Heitmeier, Vincent D Costa, Vijay K Samineni, Meaghan C Creed

Erratum issuedAbstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Unpacking Ventral Pallidum GABA Neuron Contributions to Opioid Drug Reward in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Ventral pallidal GABAergic neurons control hedonic feeding and obesity.bioRxiv : the preprint server for biology · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Lite YangDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-3647-6073
Lisa Z FangDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-5742-0864
Michelle R LynchDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0009-0000-7891-5890
Chang S XuDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA.
Hannah J HahmDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA.
Yufen ZhangDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-3306-4193
Monique R HeitmeierDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA.
Vincent D CostaDepartment of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.ORCID 0000-0002-5412-8945
Vijay K SamineniDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-9491-2793
Meaghan C CreedDepartment of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-7522-8841

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1M
Ventral pallidal transcriptional adaptations underlying punishment-resistant opioid intakeR01DA056829 · NIDA · WASHINGTON UNIVERSITY · PI Meaghan C Creed, Vijay K Samineni · 2023 to 2026
$3.2M
Neurocomputational mechanisms of explore-exploit decision making in prefrontal and motivational neural circuitsR01MH125824 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI COSTA, VINCENT D · 2021 to 2025
$3.2M
Dissecting ventral pallidal plasticity in punishment-resistant opioid self-administrationR01DA058755 · NIDA · WASHINGTON UNIVERSITY · PI Meaghan C Creed · 2023 to 2026
$2.5M
Neural Mechanisms Underlying IC/BPSR01DK128475 · NIDDK · WASHINGTON UNIVERSITY · PI SAMINENI, VIJAY K · 2021 to 2025
$2.3M
Dissecting the role of ventral pallidal projections to nucleus accumbens in reward processingR01DA049924 · NIDA · WASHINGTON UNIVERSITY · PI CREED, MEAGHAN C · 2020 to 2024
$2.0M
Spinal Mechanisms Underlying Interstitial Cystitis/Bladder Pain Syndromes (IC/BPS)R01DK139386 · NIDDK · WASHINGTON UNIVERSITY · PI Vijay K Samineni · 2024 to 2026
$2.0M
The WUSTL PREP post-bacc program to enhance doctoral readiness in neuroscienceR25NS130965 · NINDS · WASHINGTON UNIVERSITY · PI Daniel Kerschensteiner, Jose A Moron-Concepcion · 2023 to 2026
$1.4M
DEFINING THE NEURAL BASIS FOR CHRONIC BLADDER PAIN AND ITS ASSOCIATED COMORBID DISORDERSK01DK115634 · NIDDK · WASHINGTON UNIVERSITY · PI SAMINENI, VIJAY K · 2018 to 2022
$582k
NCI NIH HHS P30 CA091842NIDA NIH HHS R01 DA049924NIDA NIH HHS R01 DA056829NIDA NIH HHS R01 DA058755NIDDK NIH HHS K01 DK115634NIDDK NIH HHS P30 DK020579NIDDK NIH HHS R01 DK128475NIDDK NIH HHS R01 DK139386NIH HHS P51 OD011092NIH HHS P51 OD011132NIMH NIH HHS R01 MH125824NINDS NIH HHS R25 NS130965
6 · The paper itself

Abstract

The ventral pallidum (VP) is critical for motivated behaviors. While contemporary work has begun to elucidate the functional diversity of VP neurons, the molecular heterogeneity underlying this functional diversity remains incompletely understood. We used single-nucleus RNA sequencing and in situ hybridization to define the transcriptional taxonomy of VP cell types in mice, macaques, and baboons. We found transcriptional conservation between all three species, within the broader neurochemical cell types. Unique dopaminoceptive and cholinergic subclusters were identified and conserved across both primate species but had no homolog in mice. This harmonized consensus VP cellular atlas will pave the way for understanding the structure and function of the VP and identified key neuropeptides, neurotransmitters, and neurotransmitter receptors that could be targeted within specific VP cell types for functional investigations.

Indexed as

Basal ForebrainSingle-Cell AnalysisTranscriptomeAnimalsGene Expression ProfilingMacacaMiceNeuronsPapio

Identifiers

PMID39661664
PMCPMC11633743

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.