ArticleImmunity2024
Skin immune-mesenchymal interplay within tertiary lymphoid structures promotes autoimmune pathogenesis in hidradenitis suppurativa.
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Article in Immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36citing papers in PubMed
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36 citing papers in PubMed.
- Mature tertiary lymphoid structures in pilonidal sinus disease.JID innovations : skin science from molecules to population health · 2026Article
- Review
- Regulatory T cells in the skin: Origin, function, and plasticity.JID innovations : skin science from molecules to population health · 2026Review
- Spatial transcriptomics maps early B-cell and T-cell activation in hidradenitis suppurativa.The Journal of investigative dermatology · 2026Article
- Integrated Proteogenomics and Single-Cell Transcriptomics Prioritize Putative Protective Plasma Proteins for Hidradenitis Suppurativa.Experimental dermatology · 2026Article
- Single-cell spatial profiling identifies a mucosal-like epithelial signature in Hidradenitis suppurativa tunnels.JCI insight · 2026Article
- Tertiary Lymphoid Structure: A Potential Therapeutic Target Affecting Immune Response in Autoimmune Diseases.Clinical reviews in allergy & immunology · 2026Review
- Modeling development of tertiary lymphoid structures in pulmonary tuberculosis by 3D profiling and trajectory analysis.bioRxiv : the preprint server for biology · 2026Article
- A phenotype-to-mechanism framework links phenome-wide comorbidity architecture to molecular mechanisms and therapeutic discovery in complex diseases.medRxiv : the preprint server for health sciences · 2026Article
- Local IgG autoantibody profiles in hidradenitis suppurativa and their associations with disease features and anti-TNF therapy.JID innovations : skin science from molecules to population health · 2026Article
- A skin colonizer disrupts inflammatory and humoral immune defenses in hidradenitis suppurativa.EMBO molecular medicine · 2026Article
- Single-cell spatial transcriptomic analysis of human skin anatomy.Nature genetics · 2026Article
- Disease context dictates the cellular targets of IL-17 in inflammatory skin disease.bioRxiv : the preprint server for biology · 2026Article
- Adalimumab Treatment Modulates Vascular Changes in Hidradenitis Suppurativa Lesions in a Sex-Dependent Manner.Biomedicines · 2026Article
- IgA autoantibodies promote inflammation, Th17 polarization and fibrotic responses in hidradenitis suppurativa.Nature communications · 2026Article
- When Checkpoint Inhibitors Break Barriers: Mechanisms and Challenges of irAEs of the Skin, Gastrointestinal Tract, and Lung.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Review
- Advances in Bioprinting to Model Immune-Mediated Skin Diseases.Advanced healthcare materials · 2026Review
- Recent Advances in Microfluidic Chip Technology for Laboratory Medicine: Innovations and Artificial Intelligence Integration.Biosensors · 2026Review
- Indolent primary cutaneous B-cell lymphomas resemble persistent antigen reactions without signs of dedifferentiation.Nature communications · 2026Article
- Personalized Models of Biological Barriers and Their Diseases: Recent Progress with Organs-On-Chips.Advanced biology · 2026Review
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Authors and funding
26 authors.
Wei-Wen YuThe Hansjörg Wyss Department of Plastic Surgery, New York University Grossman School of Medicine, New York, NY, USA.
Joy N P BarrettThe Hansjörg Wyss Department of Plastic Surgery, New York University Grossman School of Medicine, New York, NY, USA.
Jie TongThe Hansjörg Wyss Department of Plastic Surgery, New York University Grossman School of Medicine, New York, NY, USA.
Meng-Ju LinThe Hansjörg Wyss Department of Plastic Surgery, New York University Grossman School of Medicine, New York, NY, USA.
Meaghan MarohnThe Hansjörg Wyss Department of Plastic Surgery, New York University Grossman School of Medicine, New York, NY, USA.
Joseph C DevlinInstitute of Systems Genetics, New York University Grossman School of Medicine, New York, NY, USA; Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, USA.
Alberto HerreraDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Juliana RemarkThe Hansjörg Wyss Department of Plastic Surgery, New York University Grossman School of Medicine, New York, NY, USA; Vilcek Institute of Graduate Biomedical Sciences, New York University Grossman School of Medicine, New York, NY, USA.
Jamie LevineThe Hansjörg Wyss Department of Plastic Surgery, New York University Grossman School of Medicine, New York, NY, USA.
Pei-Kang LiuDepartment of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Victoria FangInstitute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; The Colton Center for Autoimmunity at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Abigail M ZellmerCenter for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Derek A OldridgeInstitute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Center for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
E John WherryInstitute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; The Colton Center for Autoimmunity at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Jia-Ren LinLaboratory of Systems Pharmacology, Department of Systems Biology, Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.
Jia-Yun ChenLaboratory of Systems Pharmacology, Department of Systems Biology, Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.
Peter SorgerLaboratory of Systems Pharmacology, Department of Systems Biology, Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.
Sandro SantagataLaboratory of Systems Pharmacology, Department of Systems Biology, Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
James G KruegerLaboratory of Investigative Dermatology, The Rockefeller University, New York, NY, USA.
Kelly V RugglesInstitute of Systems Genetics, New York University Grossman School of Medicine, New York, NY, USA; Division of Precision Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA.
Fei WangDepartment of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York, NY, USA; Institute of Artificial Intelligence for Digital Health, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Chang SuDepartment of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York, NY, USA; Institute of Artificial Intelligence for Digital Health, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Sergei B KoralovDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Jun WangDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA; The Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016, USA.
Ernest S ChiuThe Hansjörg Wyss Department of Plastic Surgery, New York University Grossman School of Medicine, New York, NY, USA.
Catherine P LuThe Hansjörg Wyss Department of Plastic Surgery, New York University Grossman School of Medicine, New York, NY, USA; Department of Cell Biology, New York University Grossman School of Medicine, New York, NY, USA. Electronic address: pei-ju.lu@nyulangone.org.
Funding
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1MVirology CoreU19AI082630 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI GEORG Michael LAUER · 2009 to 2026
$48.1MSynergies among inhibitory receptors in tolerance, cancer & antiviral immunityP01AI108545 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Dario AA Vignali · 2015 to 2026
$30.8MSequencing and Viral Evolution CoreU19AI117950 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI RILEY, JAMES L. · 2015 to 2019
$12.0MRadiation and checkpoint blockade for cancer immune therapyP01CA210944 · NCI · UNIVERSITY OF PENNSYLVANIA · PI MAITY, AMIT, MINN, ANDY J · 2017 to 2022
$11.5MStudy Design and Data AnalysisP30AR069589 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth Anne Grice · 2016 to 2026
$8.6MTesting the role of BATF as a pioneer transcription factor in effector T cellsR01AI115712 · NIAID · DANA-FARBER CANCER INST · PI KADOCH, CIGALL, WHERRY, E. JOHN · 2015 to 2019
$2.9MTemporal control of differentiation and epigenetics of Exhausted CD8 T cells by ToxR01AI155577 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI WHERRY, E. JOHN · 2020 to 2024
$2.7MMolecular Mechanisms in Sweat Gland DevelopmentR01AR080136 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Catherine Pei-Ju Lu · 2023 to 2026
$2.2MMolecular mechanisms in sweat gland innervationR01AR082033 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Catherine Pei-Ju Lu · 2024 to 2026
$2.0MMultispectral imaging & analysis of intact tissue sections w/ the Perkin Elmer VectraS10OD021747 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LOOMIS, CYNTHIA A · 2016 to 2016
$359kNCI NIH HHS P01 CA210944NCI NIH HHS P30 CA016087NIAID NIH HHS P01 AI108545NIAID NIH HHS R01 AI115712NIAID NIH HHS R01 AI155577NIAID NIH HHS U19 AI082630NIAID NIH HHS U19 AI117950NIAMS NIH HHS P30 AR069589NIAMS NIH HHS R01 AR080136NIAMS NIH HHS R01 AR082033NIH HHS S10 OD021747
Abstract
Hidradenitis suppurativa (HS) is a chronic, debilitating inflammatory skin disease characterized by keratinized epithelial tunnels that grow deeply into the dermis. Here, we examined the immune microenvironment within human HS lesions. Multi-omics profiling and multiplexed imaging identified tertiary lymphoid structures (TLSs) near HS tunnels. These TLSs were enriched with proliferative T cells, including follicular helper (Tfh), regulatory (Treg), and pathogenic T cells (IL17A+ and IFNG+), alongside extensive clonal expansion of plasma cells producing antibodies reactive to keratinocytes. HS fibroblasts express CXCL13 or CCL19 in response to immune cytokines. Using a microfluidic system to mimic TLS on a chip, we found that HS fibroblasts critically orchestrated lymphocyte aggregation via tumor necrosis factor alpha (TNF-α)-CXCL13 and TNF-α-CCL19 feedback loops with B and T cells, respectively; early TNF-α blockade suppressed aggregate initiation. Our findings provide insights into TLS formation in the skin, suggest therapeutic avenues for HS, and reveal mechanisms that may apply to other autoimmune settings, including Crohn's disease.
Indexed as
Hidradenitis SuppurativaSkinTertiary Lymphoid StructuresAutoimmunityB-LymphocytesChemokine CCL19Chemokine CXCL13FibroblastsHumansKeratinocytesTumor Necrosis Factor-alphaCCL19 protein, humanChemokine CCL19Chemokine CXCL13CXCL13 protein, humanTumor Necrosis Factor-alphaCCL19CXCL13hidradenitis suppurativaHSinflammatory fibroblastlymphocyte clonal expansionsingle-cell transcriptomicssingle-cell VDJ sequencingtertiary lymphoid structureTLSTLS on a chipTNF blockade
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.