Evidence mapPaperPMID 39662967Full record

ReviewGenes & development2025

Metabolic regulation in adult and aging skeletal muscle stem cells.

Vittorio Sartorelli, Veronica Ciuffoli

Abstract readReview
In one paragraph

Review in Genes & development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Vittorio SartorelliLaboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA vittorio.sartorelli@nih.gov.
Veronica CiuffoliLaboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

Funding

Control of Adult and Aging Myogenesis ZIAAR041126 · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · 2025 to 2025
$1.3M
SIRT1, Epigenetics, and Metabolism in Skeletal Muscle Development, Regeneration, and AtrophyZIAAR041164 · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · 2025 to 2025
$1.3M
REGULATION OF MYOD POST TRANSCRIPTIONAL MODIFICATIONSZ01AR041126 · ARTHRITIS, MUSCULOSKELETAL, SKIN DIS · 2000 to 2005
Intramural NIH HHS Z01 AR041126Intramural NIH HHS ZIA AR041126Intramural NIH HHS ZIA AR041164
6 · The paper itself

Abstract

Adult stem cells maintain homeostasis and enable regeneration of most tissues. Quiescence, proliferation, and differentiation of stem cells and their progenitors are tightly regulated processes governed by dynamic transcriptional, epigenetic, and metabolic programs. Previously thought to merely reflect a cell's energy state, metabolism is now recognized for its critical regulatory functions, controlling not only energy and biomass production but also the cell's transcriptome and epigenome. In this review, we explore how metabolic pathways, metabolites, and transcriptional and epigenetic regulators are functionally interlinked in adult and aging skeletal muscle stem cells.

Indexed as

Adult Stem CellsAgingMuscle, SkeletalStem CellsAdultAnimalsCell DifferentiationEpigenesis, GeneticHumansMetabolic Networks and Pathwaysadult stem cellsepigeneticsmetabolismmuscle regenerationmuscle stem cellstranscription

Identifiers

PMID39662967
PMCPMC11789647

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.