Evidence map›Paper›PMID 39664440›Full record

ArticleActa pharmaceutica Sinica. B2024

Nonalcoholic steatohepatitis increases plasma retention of sorafenib-glucuronide in a mouse model by altering hepatocyte hopping.

Erica Toth, Hui Li, Kayla Frost, Paxton Sample, Joseph Jilek, Siennah Greenfield, Dahea You, Danielle Kozlosky, Michael Goedken, Mary F Paine and 2 more

Abstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Erica TothUniversity of Arizona, Tucson, AZ 85721, USA.
Hui LiUniversity of Arizona, Tucson, AZ 85721, USA.
Kayla FrostUniversity of Arizona, Tucson, AZ 85721, USA.
Paxton SampleUniversity of Arizona, Tucson, AZ 85721, USA.
Joseph JilekUniversity of Arizona, Tucson, AZ 85721, USA.
Siennah GreenfieldUniversity of Arizona, Tucson, AZ 85721, USA.
Dahea YouRutgers University, Piscataway, NJ 08854, USA.
Danielle KozloskyRutgers University, Piscataway, NJ 08854, USA.
Michael GoedkenRutgers University, Piscataway, NJ 08854, USA.
Mary F PaineWashington State University, Spokane, WA 99202, USA.
Lauren AleksunesRutgers University, Piscataway, NJ 08854, USA.
Nathan CherringtonUniversity of Arizona, Tucson, AZ 85721, USA.

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BRIAN T BUCKLEY · 1988 to 2026
$47.4M
SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI George S Watts · 1994 to 2026
$36.7M
TRAINING IN EVIRONMENTAL TOXICOLOGYT32ES007148 · NIEHS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI Lauren M Aleksunes · 1987 to 2026
$11.4M
Training in Environmental Toxicology of Human DiseaseT32ES007091 · NIEHS · UNIVERSITY OF ARIZONA · PI Nathan J Cherrington · 1985 to 2026
$10.7M
Renal Disposition in NASHR01ES028668 · NIEHS · UNIVERSITY OF ARIZONA · PI CHERRINGTON, NATHAN J · 2019 to 2023
$2.4M
Circumventing the Blood-Testis BarrierR01GM123643 · NIGMS · UNIVERSITY OF ARIZONA · PI CHERRINGTON, NATHAN J · 2017 to 2020
$1.2M
NIEHS NIH HHS P30 ES005022NIEHS NIH HHS P30 ES006694NIEHS NIH HHS R01 ES028668NIEHS NIH HHS T32 ES007091NIEHS NIH HHS T32 ES007148NIGMS NIH HHS R01 GM123643
6 · The paper itself

Abstract

Hepatocyte hopping is the hepatocyte-to-sinusoid-to-hepatocyte shuttling that increases the efficiency of hepatic elimination of xenobiotics. This phenomenon is mediated

Indexed as

ADMEDrug dispositionHepatocyte hoppingKnockout mouseNonalcoholic steatohepatitisSorafenibSorafenib glucuronideTransport

Identifiers

PMID39664440
PMCPMC11628858

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.