Evidence map›Paper›PMID 39664493›Full record

ArticleFrontiers in cellular and infection microbiology2024

Sustained antiviral insulin signaling during West Nile virus infection results in viral mutations.

Aditya B Char, Chasity E Trammell, Stephen Fawcett, Manish Chauhan, Yared Debebe, Nora Céspedes, Ryder A Paslay, Laura R H Ahlers, Dharmeshkumar Patel, Shirley Luckhart and 1 more

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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aditya B CharSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA, United States.
Chasity E TrammellSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA, United States.
Stephen FawcettSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA, United States.
Manish ChauhanSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA, United States.
Yared DebebeDepartment of Entomology, Plant Pathology, and Nematology, College of Agricultural and Life Sciences, University of Idaho, Moscow, ID, United States.
Nora CéspedesDepartment of Entomology, Plant Pathology, and Nematology, College of Agricultural and Life Sciences, University of Idaho, Moscow, ID, United States.
Ryder A PaslayDepartment of Entomology, Plant Pathology, and Nematology, College of Agricultural and Life Sciences, University of Idaho, Moscow, ID, United States.
Laura R H AhlersSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA, United States.
Dharmeshkumar PatelCenter for ViroScience and Cure, Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, United States.
Shirley LuckhartDepartment of Entomology, Plant Pathology, and Nematology, College of Agricultural and Life Sciences, University of Idaho, Moscow, ID, United States.
Alan G GoodmanSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arthropod-borne viruses or arboviruses, including West Nile virus (WNV), dengue virus (DENV), and Zika virus (ZIKV) pose significant threats to public health. It is imperative to develop novel methods to control these mosquito-borne viral infections. We previously showed that insulin/insulin-like growth factor-1 signaling (IIS)-dependent activation of ERK and JAK-STAT signaling has significant antiviral activity in insects and human cells. Continuous immune pressure can lead to adaptive mutations of viruses during infection. We aim to elucidate how IIS-signaling in mosquitoes selects for West Nile virus escape variants, to help formulate future transmission blocking strategies. We hypothesize that passage of WNV under activation of IIS will induce adaptive mutations or escape variants in the infecting virus. To test our hypothesis, WNV was serially passaged through

Indexed as

InsulinMutationSignal TransductionWest Nile virusAnimalsCell LineCulexHumansSerial PassageVirus ReplicationWest Nile FeverInsulinCulex quinquefasciatusDrosophila melanogasterevolutionflavivirusfruit flyIISmosquitovector

Identifiers

PMID39664493
PMCPMC11631865

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.