Evidence map›Paper›PMID 39664586›Full record

ArticleInternational journal of biological sciences2024

Smad4 Deficiency in S100A4

Ting Liu, Xinyuan Zhang, Xuanxuan Yan, Leirong Cheng, Xinlong Yan, Fanxin Zeng, Xue Li, Zhinan Chen, Jianchun Gu, Jinhua Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ting LiuSchool of Life Science and Technology, Jinan University, Guangzhou, Guangdong Province, P.R. China.
Xinyuan ZhangThe College of Life Science and Bioengineering, Beijing Jiaotong University, Beijing, P.R. China.
Xuanxuan YanThe College of Life Science and Bioengineering, Beijing Jiaotong University, Beijing, P.R. China.
Leirong ChengThe College of Life Science and Bioengineering, Beijing Jiaotong University, Beijing, P.R. China.
Xinlong YanFaculty of Environmental and Life Sciences, Beijing University of Technology, Beijing, P.R. China.
Fanxin ZengDepartment of Clinical Research Center, Dazhou Central Hospital, Dazhou, Sichuan Province, P.R. China.
Xue LiDepartment of Clinical Research Center, Dazhou Central Hospital, Dazhou, Sichuan Province, P.R. China.
Zhinan ChenSchool of Life Science and Technology, Jinan University, Guangzhou, Guangdong Province, P.R. China.
Jianchun GuDepartment of Oncology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China.
Jinhua ZhangThe College of Life Science and Bioengineering, Beijing Jiaotong University, Beijing, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

S100A4 is primarily expressed in intestinal macrophages, and promotes colonic inflammation and colitis-associated colon tumorigenesis. Smad4 is also expressed in the colon; however, it inhibits colitis-associated cancer (CAC) development. The specific role of Smad4 in S100A4

Indexed as

Lipid MetabolismMacrophagesS100 Calcium-Binding Protein A4Smad4 ProteinAnimalsAzoxymethaneCarcinogenesisColitisColitis-Associated NeoplasmsDextran SulfateHumansMaleMiceMice, Inbred C57BLAzoxymethaneDextran SulfateS100a4 protein, mouseS100 Calcium-Binding Protein A4Smad4 ProteinSmad4 protein, mouseFabp2macrophagemetabolism.S100A4Smad4STAT6

Identifiers

PMID39664586
PMCPMC11628331

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.