ArticleMedical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention2024
Adaptive Subtype and Stage Inference for Alzheimer's Disease.
Article in Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Subtype and Stage Inference (SuStaIn) is a useful Event-based Model for capturing both the temporal and the phenotypical patterns for any progressive disorders, which is essential for understanding the heterogeneous nature of such diseases. However, this model cannot capture subtypes with different progression rates with respect to predefined biomarkers with fixed events prior to inference. Therefore, we propose an adaptive algorithm for learning subtype-specific events while making subtype and stage inference. We use simulation to demonstrate the improvement with respect to various performance metrics. Finally, we provide snapshots of different levels of biomarker abnormality within different subtypes on Alzheimer's Disease (AD) data to demonstrate the effectiveness of our algorithm.
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