Evidence map›Paper›PMID 39665140›Full record

ReviewArteriosclerosis, thrombosis, and vascular biology2025

Looking Under the Hood at the Cytoskeletal Engine of Platelet Production.

Joseph E Italiano, Clementine Payne, Roelof H Bekendam

Abstract readReview
In one paragraph

Review in Arteriosclerosis, thrombosis, and vascular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joseph E ItalianoVascular Biology Program, Boston Children's Hospital, MA (J.E.I., C.P., R.H.B.).
Clementine PayneVascular Biology Program, Boston Children's Hospital, MA (J.E.I., C.P., R.H.B.).ORCID 0009-0007-8990-0150
Roelof H BekendamVascular Biology Program, Boston Children's Hospital, MA (J.E.I., C.P., R.H.B.).

Funding

The Centrosome as a master controller of platelet production.R35HL161175 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI JOSEPH E ITALIANO · 2022 to 2026
$5.3M
NHLBI NIH HHS R35 HL161175
6 · The paper itself

Abstract

Blood platelets are anucleate cells essential for normal blood hemostasis. To maintain a normal platelet count of 150 000 to 400 000 per μL of blood, 10

Indexed as

Blood PlateletsCytoskeletonMegakaryocytesThrombopoiesisActinsAnimalsCentrosomeHumansMicrotubulesSignal TransductionActinsbone marrowhemostasismegakaryocytesmicrotubulethrombopoietin

Identifiers

PMID39665140
PMCPMC12691152

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.