Evidence map›Paper›PMID 39665907›Full record

ReviewTrends in microbiology2025

The sticky business of Alphavirus capsid-host interactions.

Caroline K Martin, Peiqi Yin, Margaret Kielian

Abstract readReview
In one paragraph

Review in Trends in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Caroline K MartinDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address: caroline.martin@einsteinmed.edu.
Peiqi YinDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA.
Margaret KielianDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address: margaret.kielian@einsteinmed.edu.

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI Ulrich Steidl · 1985 to 2026
$111.2M
Molecular Analysis of Alphavirus Membrane Fusion ProteinR01AI075647 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KIELIAN, MARGARET · 2007 to 2023
$9.0M
Identification and characterization of host proteins involved in the alphavirus exit pathwayR21AI166194 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI KIELIAN, MARGARET · 2021 to 2022
$462k
Mechanisms of novel host factors in alphavirus infectionR21AI182834 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI MARTIN, CAROLINE K · 2024 to 2025
$462k
NCI NIH HHS P30 CA013330NIAID NIH HHS R01 AI075647NIAID NIH HHS R21 AI166194NIAID NIH HHS R21 AI182834
6 · The paper itself

Abstract

Alphaviruses are a serious threat to global health and can cause lethal encephalitic or arthritogenic disease in humans and animals. As there are no licensed antivirals, it is critical to improve our understanding of alphavirus interactions with the host cell. Here, we focus on the essential alphavirus protein capsid. While its roles in genome packaging and virus assembly have been well-studied, much less is known about capsid's interactions with host proteins and their functional relevance for infection. Recently, several new capsid interactor candidates were identified, collectively emphasising the complexity of capsid-host biology. In this review we summarise these novel interactor candidates, highlight capsid's emerging role in immune evasion, and discuss the challenges and opportunities arising from capsid-host interactions.

Indexed as

AlphavirusAlphavirus InfectionsCapsidCapsid ProteinsHost-Pathogen InteractionsAnimalsHumansImmune EvasionVirus AssemblyCapsid Proteinsalphaviruscapsidchikungunya virusEastern Equine Encephalitis virusSemliki Forest virusvirus–host interactions

Identifiers

PMID39665907
PMCPMC11916923

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.