ArticleJournal of neurology2024
Analyzing the relationship between specific brain structural changes and the diffusion tensor image analysis along the perivascular space index in idiopathic normal pressure hydrocephalus.
Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Diffusion tensor image analysis along the perivascular space (DTI-ALPS): redefining its interpretation and role.Japanese journal of radiology · 2026Review
- Impact of neurovascular coupling and glymphatic function on cognitive function in asymptomatic cerebral small vessel disease.Frontiers in neurology · 2026Article
- Multimodal MRI Combined with Cognitive Evaluation Reveals Glymphatic System Impairment in Moyamoya Vasculopathy.Current neurovascular research · 2026Article
- Glymphatic dysfunction and cognitive impairment in tuberculous meningitis: insights from diffusion tensor imaging along the perivascular space (DTI-ALPS).Frontiers in neuroscience · 2026Article
- Alterations of Glymphatic System Before and After Shunt Surgery in Patients With Idiopathic Normal Pressure Hydrocephalus: A Longitudinal Study.European journal of neurology · 2025Article
- Review
- Multimodal DTI-ALPS and hippocampal microstructural signatures unveil stage-specific pathways in Alzheimer's disease progression.Frontiers in aging neuroscience · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiffusion Tensor Image Analysis Along the Perivascular Space (DTI-ALPS) evaluates the glymphatic system in patients with idiopathic normal-pressure hydrocephalus (iNPH). However, white matter compression due to ventricular enlargement may affect the ALPS index. This study aimed to investigate the relationship among the ALPS index, white matter changes, and clinical symptoms in patients with iNPH.
methodsWe calculated the ALPS index in 30 patients with iNPH, aged 70 and above, using DTI data and correlated it with various clinical and imaging indices, including the Evans index, callosal angle, cognitive tests, gait assessment (timed up-and-go [TUG] test), cerebrospinal fluid (CSF) medullary pressure, and various DTI indices (axial diffusivity [AD], radial diffusivity [RD], mean diffusivity [MD], fractional anisotropy [FA]).
resultsSignificant negative correlations were observed between the ALPS index and the rate of change in step count in the TUG test after the tap test (r = -0.5014, p = 0.0048), as well as CSF medullary pressure (r = -0.4651, p = 0.0096). Positive correlations were identified between the ALPS index and both AD (r = 0.4984, p = 0.0051) and MD (r = 0.3631, p = 0.0486).
conclusionA lower ALPS index was associated with gait improvement following the tap test as well as higher CSF medullary pressure. The ALPS index may detect subtle periventricular compression-induced changes in iNPH. Consequently, it could potentially serve as a predictor for tap test effectiveness in patients with iNPH, offering a new perspective on its application in iNPH diagnosis and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.