Evidence map›Paper›PMID 39666174›Full record

Observational studyInternational urology and nephrology2025

The association between the presence of kidney stones and the risk of developing osteoporosis: a NHANES-based cross-sectional study and Mendelian randomization analysis.

Juefei Dong, Weibin Hou, Guangming Yin, Jinrong Wang, Long Wang, Jianye Liu, Xianzhen Jiang, Jing Tan

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in International urology and nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Juefei DongDepartment of Urology, The Third Xiangya Hospital, Central South University, Changsha, 410000, Hunan, China.
Weibin HouDepartment of Urology, The Third Xiangya Hospital, Central South University, Changsha, 410000, Hunan, China.
Guangming YinDepartment of Urology, The Third Xiangya Hospital, Central South University, Changsha, 410000, Hunan, China.
Jinrong WangDepartment of Urology, The Third Xiangya Hospital, Central South University, Changsha, 410000, Hunan, China.
Long WangDepartment of Urology, The Third Xiangya Hospital, Central South University, Changsha, 410000, Hunan, China.
Jianye LiuDepartment of Urology, The Third Xiangya Hospital, Central South University, Changsha, 410000, Hunan, China.
Xianzhen JiangDepartment of Urology, The Third Xiangya Hospital, Central South University, Changsha, 410000, Hunan, China.
Jing TanDepartment of Urology, The Third Xiangya Hospital, Central South University, Changsha, 410000, Hunan, China. tanjing@csu.edu.cn.

Funding

the Natural Science Foundation of Hunan Province No. 2024JJ5527
6 · The paper itself

Abstract

purposeTo investigate whether the presence of kidney stones increases the risk of developing osteoporosis.

methodsFirst, we performed an observational study on the basis of data from the National Health and Nutrition Examination Survey (NHANES; 2007-2020). Kidney stone patients were identified on the basis of their affirmative response to the question "Have you ever experienced kidney stones?" (KIQ026). Participants whose T score at the femoral neck was < -2.5 were defined as osteoporosis patients. Multivariable-adjusted logistic regression was used to assess the correlation between the presence of kidney stones and the risk of developing osteoporosis. Second, Mendelian randomization (MR) was applied to further investigate the causal relationship between the presence of kidney stones and the risk of developing osteoporosis. Genetic instruments were obtained from large genome-wide association studies (GWASs) from the UK Biobank and FinnGen Biobank. Inverse-variance weighting (IVW) was the primary analytical method used.

resultsAfter adjustment for demographic and other covariates, a significant association between the presence of kidney stones and the risk of developing osteoporosis was detected (OR 1.778, CI: 1.345-2.351, P < 0.001). The MR results further revealed that genetically speaking, the presence of kidney stones was causally associated with a greater risk of developing osteoporosis (IVW: OR 1.088, CI: 1.015-1.167, P < 0.05).

conclusionThe presence of kidney stones is associated with an increased risk of developing osteoporosis. Further prospective cohort studies are needed to validate our results.

Indexed as

Kidney CalculiOsteoporosisAdultAgedCross-Sectional StudiesFemaleHumansMaleMendelian Randomization AnalysisMiddle AgedNutrition SurveysRisk FactorsKidney stonesMendelian randomizationNational Health and Nutrition Examination SurveyOsteoporosis

Identifiers

PMID39666174

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.