Evidence map›Paper›PMID 39666783›Full record

ArticlePlant biotechnology journal2025

Rational design of azo-aminopyrimidine derivatives as the potent lepidoptera-exclusive chitinase inhibitors.

Baokang Ding, Shujie Ma, Meiling Yang, Quanguo Zhang, Xiujia Hua, Jiahao Zhang, Shenmeng Bai, Lihui Zhang, Jingao Dong, Shengqiang Shen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Baokang Ding *College of Plant Protection/State Key Laboratory of North China Crop Improvement and Regulation, Hebei Agricultural University, Baoding, China.ORCID https://orcid.org/0009-0006-0368-2360
Shujie Ma *College of Plant Protection/State Key Laboratory of North China Crop Improvement and Regulation, Hebei Agricultural University, Baoding, China.ORCID https://orcid.org/0000-0001-8181-6586
Meiling Yang *College of Plant Protection/State Key Laboratory of North China Crop Improvement and Regulation, Hebei Agricultural University, Baoding, China.
Quanguo ZhangInstitute of Cereal and Oil Crops, Hebei Academy of Agricalture and Foristry Sciences, Shijiazhuang, China.
Xiujia HuaCollege of Plant Protection/State Key Laboratory of North China Crop Improvement and Regulation, Hebei Agricultural University, Baoding, China.
Jiahao ZhangCollege of Plant Protection/State Key Laboratory of North China Crop Improvement and Regulation, Hebei Agricultural University, Baoding, China.
Shenmeng BaiCollege of Plant Protection/State Key Laboratory of North China Crop Improvement and Regulation, Hebei Agricultural University, Baoding, China.
Lihui ZhangCollege of Plant Protection/State Key Laboratory of North China Crop Improvement and Regulation, Hebei Agricultural University, Baoding, China.
Jingao DongCollege of Plant Protection/State Key Laboratory of North China Crop Improvement and Regulation, Hebei Agricultural University, Baoding, China.
Shengqiang ShenCollege of Life Sciences, Hebei Agricultural University, Baoding, China.
Lili DongCollege of Plant Protection/State Key Laboratory of North China Crop Improvement and Regulation, Hebei Agricultural University, Baoding, China.

Funding

The Central guide Local Science and Technology Development Fund Project of Hebei Province 236Z6506GThe Key Research and Development Project of Hebei Province 22326508DThe National Natural Science Foundation 32102247The National Natural Science Foundation 32472591The Talents Introduction Program in Hebei Agricultural University YJ2021021
6 · The paper itself

Abstract

Ostrinia furnacalis (O. furnacalis) is a commonly occurring agricultural pest that can severely impact corn yield and quality. Therefore, establishing and implementing effective control methods against O. furnacalis are of great significance. Chemical insecticides remain the most effective means to mitigate the damage caused by O. furnacalis. With the increasing resistance of O. furnacalis to insecticides, it is imperative to identify and develop compounds with novel mechanisms of action and high safety. The chitinase OfChi-h, identified and characterized in O. furnacalis, has been recognized as a potential insecticide target. In this study, a series of azo-aminopyrimidine analogues were synthesized as OfChi-h inhibitors employing rational molecular optimization. Among them, compounds 9b, 10a and 10g exhibited K

Indexed as

Azo CompoundsChitinasesEnzyme InhibitorsInsecticidesLepidopteraMothsPyrimidinesAnimalsDrug DesignLarvaMolecular Docking SimulationAzo CompoundsChitinasesEnzyme InhibitorsInsecticidesPyrimidinesazo‐aminopyrimidinechitinaseinsecticideOfChi‐hpot experiments

Identifiers

PMID39666783
PMCPMC11869178

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.