ArticleScience (New York, N.Y.)2024
A long noncoding eRNA forms R-loops to shape emotional experience-induced behavioral adaptation.
Abstract read
In one paragraph
Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Structure-driven function of plant lncRNAs: conserved RNA architectures in transcriptional and post-transcriptional regulation.RNA biology · 2026Review
- Regulation of neuronal transcription by RNA-binding proteins via R-loop dynamics.Neural regeneration research · 2026Article
- Neuronal activity-driven 3D chromatin dynamics in cortical pyramidal neurons depend on SATB2.Nucleic acids research · 2026Article
- Temporal dynamics of intragenic enhancer RNAs regulate Lin28a expression in response to external stimuli in embryonic stem cells.Nucleic acids research · 2026Article
- When circular RNAs meet the genome: CiR-loops as chromatin regulators and disease drivers.Nucleic acids research · 2026Review
- The role of non-coding RNAs in regulating R-loop dynamics in cancer: Mechanisms and therapeutic implications.Acta pharmaceutica Sinica. B · 2026Review
- Cocaine Hijacks the Npas4-dependent Somatostatin Ensembles in the mPFC to Mediate Attention.Neuroscience bulletin · 2026Article
- R-loop homeostasis at transposable elements safeguards transcriptional silencing in replication-quiescent oocytes.Nature communications · 2026Article
- When R-Loops Go Awry: Genome Instability and Neurological Diseases.The European journal of neuroscience · 2026Review
- Metamorphosis and lncRNAs: A Close Relationship.Genesis (New York, N.Y. : 2000) · 2026Review
- Histone Deacetylase 5 in Prelimbic Prefrontal Cortex Limits Context-Associated Cocaine Seeking.Biological psychiatry · 2026Article
- Deciphering the regulatory landscape of enhancer RNAs in health and disease.Signal transduction and targeted therapy · 2026Review
- Emerging insights into enhancer RNAs: biogenesis, function, mechanism, and disease implication.Briefings in bioinformatics · 2026Review
- Advances in the Mechanism of ceRNA Regulation in Postoperative Cognitive Dysfunction.Current neuropharmacology · 2026Review
- Transcription factors implicated in substance use disorder, from immediate early genes to altered gene expression.Brain research · 2026Review
- Article
- Profiling fear-extinction learning induced small ncRNAs landscape and identifying miR-29b-3p as a promising biomarker for PTSD.Journal of translational medicine · 2025Article
- Super enhancer lncRNA RP11-54O7.17 regulates the proliferation and metastasis of triple-negative breast cancer by targeting lysosomal degradation of S100A4.Cell death & disease · 2025Article
- Intersection of transient cell states with stable cell types in hippocampus.bioRxiv : the preprint server for biology · 2025Article
- Revisiting models of enhancer-promoter communication in gene regulation.Genome research · 2025Review
Corrections and comments
- Commented on by
Authors and funding
13 authors.
Rose Marie AkikiDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.ORCID 0000-0001-8141-5344
Rebecca G CornbrooksDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.ORCID 0009-0003-5086-2557
Kosuke MagamiDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.
Alain GreigeDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.ORCID 0009-0007-0811-8416
Kirsten K SnyderDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.
Daniel J WoodDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.ORCID 0000-0003-1874-7738
Mary Claire HerringtonDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.
Philip MaceDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.
Kyle BlidyDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.ORCID 0000-0001-6997-7221
Nobuya KoikeDepartment of Physiology and Systems Bioscience, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Stefano BertoDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.
Christopher W CowanDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.ORCID 0000-0001-5472-3296
Makoto TaniguchiDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.ORCID 0000-0001-6356-2463
Funding
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1MDRUG ABUSE TRAINING PROGRAMT32DA007288 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Christopher W Cowan, Rachel Penrod-Martin · 1991 to 2026
$11.8MThe Role of Early Life Stress in Feeding BehaviorsP20GM148302 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Jose H Ledo · 2023 to 2026
$11.5MCOCA: Project 4. Neurocircuit Strategy to Decrease Cocaine Cue ReactivityP50DA046373 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HANLON, COLLEEN A · 2019 to 2023
$9.9MSouth Carolina COBRE in Oxidants, Redox Balance and Stress SignalingP30GM140964 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI EBLEN, SCOTT T · 2021 to 2025
$6.4MRole of Class IIa HDAC Target Genes in Opioid and Cocaine AddictionR01DA032708 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI COWAN, CHRISTOPHER W · 2013 to 2022
$3.8MLong non-coding enhancer RNA controls stress-induced changes in reward-related behaviorsR01MH129521 · NIMH · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Makoto Taniguchi · 2023 to 2026
$1.5MNCATS NIH HHS UL1 TR001450NIDA NIH HHS P50 DA046373NIDA NIH HHS R01 DA032708NIDA NIH HHS T32 DA007288NIGMS NIH HHS P20 GM148302NIGMS NIH HHS P30 GM140964NIMH NIH HHS R01 MH129521
Abstract
Emotional experiences often evoke neural plasticity that supports adaptive changes in behavior, including maladaptive plasticity associated with mood and substance use disorders. These adaptations are supported in part by experience-dependent activation of immediate-early response genes, such as
Indexed as
Adaptation, PsychologicalBasic Helix-Loop-Helix ProteinsCocaineEmotionsEnhancer Elements, GeneticRNA, Long NoncodingStress, PsychologicalAnimalsBehavior, AnimalChromatinMaleMiceMice, Inbred C57BLNeuronal PlasticityPromoter Regions, GeneticR-Loop StructuresBasic Helix-Loop-Helix ProteinsChromatinCocaineNpas4 protein, mouseRNA, Long Noncoding
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.