ArticleScience (New York, N.Y.)2024
An injury-induced mesenchymal-epithelial cell niche coordinates regenerative responses in the lung.
Abstract read
In one paragraph
Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed.
- Trop-1/EpCAM Thr115 is a driver of hyperproliferative cell repair and of severe lung damage in COVID-19.iScience · 2026Article
- Collagenase-Coated Polymeric Drug/siRNA Nanoparticles Overcome ECM and Regulate Metabolic Reprogramming of Fibroblasts for Alleviating Pulmonary Fibrosis.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- ERS Congress 2025: highlights from the Basic and Translational Sciences Assembly.ERJ open research · 2026Article
- Cytoskeletal-nuclear control of alveolar fibroblast identity directs lung regeneration.bioRxiv : the preprint server for biology · 2026Article
- Concerted action of gammaherpesvirus infection and moderate hyperoxia on lung structural development including effects on critical lung fibroblast functions in neonatal mice.Molecular and cellular pediatrics · 2026Article
- Dysregulated ITGA3/FAK/YAP axis mediates impaired alveolar type II epithelial cells function in COPD.Journal of advanced research · 2026Article
- Extracellular matrix stiffness directs region-specific lung epithelial differentiation revealed by hPSC-derived lung organoids.Nature communications · 2026Article
- High numerical aperture confocal volumetric mesoscope reveals mesoscale subcellular dynamics in vivo.Nature biotechnology · 2026Article
- Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66cAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- RUNX1 is a mediator of fibrotic activation and epigenetic memory in lung fibroblasts.American journal of respiratory cell and molecular biology · 2026Article
- MSCs/EVs-based therapy targeting DAD: research progress and future perspectives from ARDS and COVID-19 to RP-ILD.Stem cell research & therapy · 2026Review
- Multi-omics analysis of glutamine and fish collagen peptides in alleviating post-antibioticExperimental and therapeutic medicine · 2026Article
- Fibroblasts as regulators of lung immunity, repair and fibrosis.Nature reviews. Immunology · 2026Review
- Beyond the epithelium: multicellular niches in lung regeneration and disease.American journal of physiology. Lung cellular and molecular physiology · 2026Review
- Chronic TGFβ1 Signaling Drives Aberrant Alveolar-Basaloid Metaplasia through a KRT17-Stratifin migratory complex.bioRxiv : the preprint server for biology · 2026Article
- Article
- Dietary intake and BCAA metabolism regulate pulmonary fibrosis through KDM4A-mediated epigenetic remodeling in male mice.Nature communications · 2026Article
- Mapping cellular and ECM heterogeneity in pulmonary fibrosis - insights from recent spatiomics studies.Cell biomaterials · 2026Article
- Pulmonary organoid models demonstrate compositionally driven epithelial plasticity and immune polarization.iScience · 2026Article
- Myeloperoxidase promotes fibrosis by inhibiting cathepsin K to bias the lung toward ECM accumulation.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Dakota L JonesDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-3944-5686
Michael P MorleyDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-0958-7376
Xinyuan LiDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0009-0005-5765-793X
Yun YingDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-2306-0949
Gan ZhaoDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-8043-6036
Sarah E SchaeferDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0009-0002-2360-781X
Luis R RodriguezDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-7176-0697
Fabian L Cardenas-DiazDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-6504-478X
Shanru LiDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0009-0009-7851-7468
Su ZhouDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ullas V ChembazhiDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-6305-3156
Mijeong KimDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-0678-366X
Chen ShenDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-7119-8443
Ana NottinghamDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-9657-5885
Susan M LinDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-2415-8350
Edward CantuDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-1105-0129
Joshua M DiamondDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-3695-4637
Maria C BasilDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-4716-1285
Andrew E VaughanDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-5740-643X
Edward E MorriseyDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-5785-1939
Funding
Genetic Investigation of Covid 19 in Lung DiseaseR01HL164929 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MARK L KAHN, EDWARD E MORRISEY · 2022 to 2026
$4.7MMolecular pathways controlling alveolar epithelial remodeling in development and regenerationR01HL132999 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MORRISEY, EDWARD E · 2016 to 2023
$4.6MMulti-modal characterization of three human lung niches at the single cell levelU01HL148857 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MORRISEY, EDWARD E · 2019 to 2023
$4.4MMechanical signaling through the nuclear membrane in lung alveolar healthR01HL168803 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI EDWARD E MORRISEY · 2023 to 2026
$3.1MObjective Lung Assessment Tools for Improved Organ Use in Lung TransplantationR01HL155821 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CANTU, EDWARD · 2021 to 2025
$3.0MTranscriptional Regulation of Lung Alveolar RegenerationR01HL152194 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MORRISEY, EDWARD E · 2021 to 2024
$2.3MControl of lung alveolar regeneration by Dot1L/H3K79 methylationR01HL162683 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI EDWARD E MORRISEY · 2023 to 2026
$2.3MCoordinated regeneration of lung epithelial and endothelial compartmentsR01HL164350 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI VAUGHAN, ANDREW · 2022 to 2025
$2.2MSolitary chemosensory / tuft cells in lung regeneration and inflammationR01HL153539 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI VAUGHAN, ANDREW · 2020 to 2024
$2.0MMolecular regulation of cell fate and progenitor function in the distal human respiratory airwaysK08HL163398 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Maria Ciocca Basil · 2022 to 2026
$834kMesenchymal cell plasticity and signaling in lung regenerationR00HL173656 · NHLBI · UNIVERSITY OF IOWA · PI Dakota L Jones · 2025 to 2026
$498kMesenchymal cell plasticity and signaling in lung regenerationK99HL173656 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI JONES, DAKOTA L · 2024 to 2024
$157kNHLBI NIH HHS K08 HL163398NHLBI NIH HHS K99 HL173656NHLBI NIH HHS L30 HL165571NHLBI NIH HHS R00 HL173656NHLBI NIH HHS R01 HL132999NHLBI NIH HHS R01 HL152194NHLBI NIH HHS R01 HL153539NHLBI NIH HHS R01 HL155821NHLBI NIH HHS R01 HL162683NHLBI NIH HHS R01 HL164350NHLBI NIH HHS R01 HL164929NHLBI NIH HHS R01 HL168803NHLBI NIH HHS U01 HL148857
Abstract
Severe lung injury causes airway basal stem cells to migrate and outcompete alveolar stem cells, resulting in dysplastic repair. We found that this "stem cell collision" generates an injury-induced tissue niche containing keratin 5
Indexed as
LungLung InjuryMesenchymal Stem CellsReceptors, NotchRegenerationStem Cell NicheAlveolar Epithelial CellsAnimalsCell ProliferationEpithelial CellsHumansKeratin-5MicePulmonary AlveoliReceptor, Platelet-Derived Growth Factor alphaSignal TransductionKeratin-5Receptor, Platelet-Derived Growth Factor alphaReceptors, Notch
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.