Evidence map›Paper›PMID 39667419›Full record

ArticleBone2025

RANK IVVY motif plays crucial roles in osteoclastogenesis.

Shenyuan Chen, Zhenqi Shi, Joel Jules, Yuyu Li, Robert A Kesterson, Mohamed Halaby Elbahoty, Ping Zhang, Xu Feng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shenyuan ChenDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA; The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China; Chongqing Key Laboratory of Oral Diseases, Chongqing, China.
Zhenqi ShiDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Joel JulesDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Yuyu LiDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Robert A KestersonDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.
Mohamed Halaby ElbahotyDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Internal Medicine, Alexandria University, Alexandria, Egypt.
Ping ZhangDepartment of Pediatric Dentistry, School of Dentistry, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: pingz@uab.edu.
Xu FengDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: xfeng@uabmc.edu.

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9M
ROS Modulation of Innate and Adaptive Immunity in RAP30AR048311 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MOUNTZ, JOHN D · 2001 to 2017
$9.5M
RANK Signaling in Osteoclast Differentiation &FunctionR01AR047830 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FENG, XU · 2001 to 2016
$4.7M
ROLE OF OSTEOCLAST PRECURSORS IN PERIODONTAL BONE LOSSR01DE026465 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZHANG, PING · 2017 to 2021
$2.1M
IMPORTANCE OF PERIODONTITIS IN THE INNATE IMMUNE REGULATION OF ALZHEIMER'S DISEASER01AG078708 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Ping Zhang · 2023 to 2026
$1.5M
NCI NIH HHS P30 CA013148NIAMS NIH HHS P30 AR048311NIAMS NIH HHS R01 AR047830NIA NIH HHS R01 AG078708NIDCR NIH HHS R01 DE026465
6 · The paper itself

Abstract

RANKL and its receptor RANK play a vital role in osteoclastogenesis. RANK primarily recruits TRAFs to promote osteoclastogenesis but also contains an TRAF-independent motif (IVVY

Indexed as

OsteoclastsOsteogenesisReceptor Activator of Nuclear Factor-kappa BAmino Acid MotifsAnimalsCell DifferentiationMacrophagesMaleMiceMice, Inbred C57BLNFATC Transcription FactorsRANK LigandX-Ray MicrotomographyNFATC Transcription FactorsRANK LigandReceptor Activator of Nuclear Factor-kappa BOsteoclastPorphyromonas gingivalisRANKLRANK Signaling

Identifiers

PMID39667419
PMCPMC11761383

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.