Evidence map›Paper›PMID 39667502›Full record

ArticleThe Journal of biological chemistry2025

Iron regulatory protein 1-deficient mice exhibit hypospermatogenesis.

Aileen Harrer, Niraj Ghatpande, Tiziana Grimaldini, Daniela Fietz, Vishnu Kumar, Christiane Pleuger, Monika Fijak, Dankward T Föppl, Lennart P Rynio, Hans-Christian Schuppe and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Aileen HarrerInstitute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig-University of Giessen, Giessen, Germany; Hessian Centre of Reproductive Medicine, Justus-Liebig-University Giessen, Giessen, Germany.
Niraj GhatpandeFaculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Technion City, Haifa, Israel.
Tiziana GrimaldiniInstitute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig-University of Giessen, Giessen, Germany; Hessian Centre of Reproductive Medicine, Justus-Liebig-University Giessen, Giessen, Germany.
Daniela FietzHessian Centre of Reproductive Medicine, Justus-Liebig-University Giessen, Giessen, Germany; Institute for Veterinary Anatomy, Histology and Embryology, Justus-Liebig-University of Giessen, Giessen, Germany.
Vishnu KumarInstitute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig-University of Giessen, Giessen, Germany; Hessian Centre of Reproductive Medicine, Justus-Liebig-University Giessen, Giessen, Germany.
Christiane PleugerInstitute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig-University of Giessen, Giessen, Germany; Hessian Centre of Reproductive Medicine, Justus-Liebig-University Giessen, Giessen, Germany.
Monika FijakInstitute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig-University of Giessen, Giessen, Germany; Hessian Centre of Reproductive Medicine, Justus-Liebig-University Giessen, Giessen, Germany.
Dankward T FöpplInstitute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig-University of Giessen, Giessen, Germany; Hessian Centre of Reproductive Medicine, Justus-Liebig-University Giessen, Giessen, Germany.
Lennart P RynioInstitute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig-University of Giessen, Giessen, Germany; Hessian Centre of Reproductive Medicine, Justus-Liebig-University Giessen, Giessen, Germany.
Hans-Christian SchuppeHessian Centre of Reproductive Medicine, Justus-Liebig-University Giessen, Giessen, Germany; Department of Urology, Pediatric Urology and Andrology, Justus-Liebig-University of Giessen, Giessen, Germany.
Adrian PilatzHessian Centre of Reproductive Medicine, Justus-Liebig-University Giessen, Giessen, Germany; Department of Urology, Pediatric Urology and Andrology, Justus-Liebig-University of Giessen, Giessen, Germany.
Marek BartkuhnBiomedical Informatics and Systems Medicine, Science Unit for Basic and Clinical Medicine, Justus-Liebig-University of Giessen, Giessen, Germany.
Tara Procida-KowalskiBiomedical Informatics and Systems Medicine, Science Unit for Basic and Clinical Medicine, Justus-Liebig-University of Giessen, Giessen, Germany.
Noga Guttmann-RavivFaculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Technion City, Haifa, Israel.
Sudhanshu BhushanInstitute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig-University of Giessen, Giessen, Germany; Hessian Centre of Reproductive Medicine, Justus-Liebig-University Giessen, Giessen, Germany.
Esther G Meyron-HoltzFaculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology, Technion City, Haifa, Israel.
Andreas MeinhardtInstitute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig-University of Giessen, Giessen, Germany; Hessian Centre of Reproductive Medicine, Justus-Liebig-University Giessen, Giessen, Germany. Electronic address: andreas.meinhardt@anatomie.med.uni-giessen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Imbalances in testicular iron levels are linked to compromised sperm production and male infertility. Iron regulatory proteins (IRP) 1 and 2 play crucial roles in cellular iron regulation. We investigated the role of IRP1 on spermatogenesis using Irp1-deficient mice (Irp1

Indexed as

Iron Regulatory Protein 1OligospermiaSpermatogenesisAnimalsIronMaleMiceMice, KnockoutOxidative StressReactive Oxygen SpeciesTestisIronIron Regulatory Protein 1Reactive Oxygen SpeciesDNA damageDNA repairiron homeostasisIRP1reactive oxygen species (ROS)spermatogenesistestis

Identifiers

PMID39667502
PMCPMC11758943

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.