Evidence map›Paper›PMID 39667712›Full record

ArticleExperimental gerontology2025

A descriptive analysis of sarcopenia markers in young adults with down syndrome.

Brett S Nickerson, Michael R Esco, George Schaefer, Elroy J Aguiar, Stefan A Czerwinski

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In one paragraph

Article in Experimental gerontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Brett S NickersonSchool of Health and Rehabilitation Sciences, The Ohio State University, Columbus, OH, USA. Electronic address: brett.nickerson@osumc.edu.
Michael R EscoDepartment of Kinesiology, The University of Alabama, Tuscaloosa, AL, USA.
George SchaeferDepartement of Kinesiology, Auburn University Montgomery, Montgomery, AL, USA.
Elroy J AguiarDepartment of Kinesiology, The University of Alabama, Tuscaloosa, AL, USA.
Stefan A CzerwinskiSchool of Health and Rehabilitation Sciences, The Ohio State University, Columbus, OH, USA.

Funding

Improving Body Composition Assessment and Physical Activity Monitoring in Adults with Down Syndrome using Mobile TechnologyR21HD115191 · NICHD · OHIO STATE UNIVERSITY · PI ESCO, MICHAEL, NICKERSON, BRETT STEPHEN · 2024 to 2025
$438k
NICHD NIH HHS R21 HD115191
6 · The paper itself

Abstract

backgroundMost body composition research in individuals with Down Syndrome (DS) has focused on overweight and obesity. Although limited research has shown muscle mass indexes and physical performance levels of adults with DS are similar to or lower than older adults with sarcopenia, there is still a large gap in the literature regarding sarcopenia.

objectiveThis brief report provides a comprehensive descriptive analysis of sarcopenia and obesity markers in individuals with DS.

methodsFourteen young adults (age = 26 ± 9 yrs.) with DS (males: n = 6; females: n = 8) had appendicular skeletal muscle mass (ASM) measured with bioimpedance analysis and handgrip strength (HGS) measured with a hand dynamometer (dominant hand). Sarcopenia was computed using the European Working Group on Sarcopenia in Older People revised definition (EWGSOP2).

resultsThe BMI for the entire group was 24.41 ± 4.01 kg/m

conclusionAn alarming number of young adults with DS had sarcopenia, and low HGS and ASM when using the EWGSOP2 definition. Health professionals are encouraged to screen for sarcopenia in young adulthood rather than deferring it to a later stage in life for individuals with DS.

Indexed as

Body Mass IndexDown SyndromeHand StrengthMuscle, SkeletalSarcopeniaAdolescentAdultBiomarkersBody CompositionElectric ImpedanceFemaleHumansMaleObesityYoung AdultBiomarkersBody compositionMuscle massMuscle qualityMuscular strengthTrisomy 21

Identifiers

PMID39667712
PMCPMC12148072

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.