Evidence map›Paper›PMID 39668274›Full record

ReviewAdvances in experimental medicine and biology2025

Breaking Down Bone Disease in People Living with HIV: Pathophysiology, Diagnosis, and Treatment.

Valeria Hasenmajer, Nicolò Francesco D'Addario, Ilaria Bonaventura, Valentina Sada, Christopher Nardi, Emmanuele Angelo Jannini, Gabriella D'Ettorre, Claudio Mastroianni, Daniele Gianfrilli

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. The effects of SARS-CoV-2 on bone homeostasis.Frontiers in endocrinology · 2026
    Review
  2. Geriatric syndromes in women living with HIV.Current opinion in HIV and AIDS · 2026
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Valeria HasenmajerDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy. valeria.hasenmajer@uniroma1.it.
Nicolò Francesco D'AddarioDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Ilaria BonaventuraDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Valentina SadaDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Christopher NardiDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Emmanuele Angelo JanniniEndocrinology and Medical Sexology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Gabriella D'EttorreDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Claudio MastroianniDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Daniele GianfrilliDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy. daniele.gianfrilli@uniroma1.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone health in people living with HIV (PLWH) has emerged as a significant concern in the era of effective antiretroviral therapy (ART). While ART has transformed HIV infection into a chronic condition, it has also unmasked long-term health complications, including an increased risk of osteoporosis and fractures. This review aims to elucidate the multifactorial mechanisms contributing to bone health deterioration in PLWH, such as direct viral effects, immune activation, and ART-induced bone metabolism changes. We examine the current evidence on bone mineral density (BMD) reductions and the heightened fracture risk in this population. Furthermore, we evaluate diagnostic and management strategies, including radiological and non-radiological evaluations, vitamin D optimization, bisphosphonates, and other emerging treatments, to provide a comprehensive overview of effective interventions. By synthesizing the latest research, this review seeks to enhance the understanding of bone health issues in PLWH and guide clinicians in implementing strategies to mitigate these risks, ultimately improving patient outcomes.

Indexed as

Anti-HIV AgentsBone DiseasesFractures, BoneHIV InfectionsOsteoporosisBone DensityBone Density Conservation AgentsHumansVitamin DAnti-HIV AgentsBone Density Conservation AgentsVitamin DBisphosphonatesBone healthHIVOsteoporosisVitamin D

Identifiers

PMID39668274

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.