ReviewMedical science monitor : international medical journal of experimental and clinical research2024
Skin Barrier Dysfunction in Acne Vulgaris: Pathogenesis and Therapeutic Approaches.
Review in Medical science monitor : international medical journal of experimental and clinical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hydrogels for acne treatment: a systematic review and meta-analysis of clinical trials.Nanomedicine (London, England) · 2026Pooled it
- The Effect of Microneedling Mesotherapy, Chemical Exfoliation and Combination Therapy on Selected Skin Parameters and Cutibacterium acnes Colonization in Women With Oily Skin.Journal of cosmetic dermatology · 2026Trial
- Efficacy of Fire Needle Therapy Combined with Doxycycline Hydrochloride in the Management of Moderate-to-Severe Acne Vulgaris: A Randomized Controlled Trial.Journal of multidisciplinary healthcare · 2025Trial
- Pipa Qingfei Yin Ameliorates Acne Inflammation in Mice via Suppressing Neutrophil Extracellular Traps.Microbiology and immunology · 2026Article
- Effectiveness of a rhGM-CSF-Containing Gel on Promoting Wound Healing After 1927-nm Fractional Thulium Fiber Laser Treatment of Atrophic Acne Scars: A Prospective, Randomized, Split-Face, and Evaluator-Blinded Clinical Trial.Aesthetic plastic surgery · 2026Article
- Mediating Effect of Sleep Quality on the Association Between Psychological Stress and Acne Vulgaris in Chinese College Students: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Enhancing Antibacterial Activity ofPharmaceuticals (Basel, Switzerland) · 2026Article
- Sulforaphane in Cutaneous Disorders and Skin Injury: Mechanisms, Evidence, and Clinical Perspectives.Nutrients · 2026Review
- Comparison of Substances in Combined Oral Contraceptives Used in Acne Vulgaris, Hirsutism, Migraine, and Dysmenorrhea.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- Spatial transcriptomics identifies differentiation, lipid metabolism, and retinoid pathway alterations in acne vulgaris.JCI insight · 2026Article
- Multimodal Management of Facial Acne Scarring Using Energy-Based Devices and Injectable Therapies: A Case Report.Cureus · 2026Article
- Protective Effect of Peony (Molecules (Basel, Switzerland) · 2025Article
- Rebalancing the Skin: The Microbiome, Acne Pathogenesis, and the Future of Natural and Synthetic Therapies.Molecules (Basel, Switzerland) · 2025Review
- Lyophilized Cell-Free Supernatants ofLife (Basel, Switzerland) · 2025Article
- Chitosan Nanoparticles Loaded with Polyphenols for Cosmeceutical Applications: A State-of-the-Art Review.Pharmaceutics · 2025Review
- Skin Barrier Dysfunction in Chronic Dermatoses: From Pathophysiology to Emerging Therapeutic Strategies.Cureus · 2025Review
- The Sebaceous Gland: A Key Player in the Balance Between Homeostasis and Inflammatory Skin Diseases.Cells · 2025Review
- Polymorphisms in MTNR1A (rs2119882) and CLOCK (rs1801260) genes are associated with facial acne susceptibility in gas station workers.PloS one · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acne vulgaris is a chronic inflammatory disease of the hair follicle-sebaceous gland unit and is the most common skin disorder worldwide. Although it can occur at any age, it predominantly affects young individuals, manifesting as comedones, papules, pustules, cysts, and nodules, primarily in the sebaceous-rich areas of the face, often in a symmetrical distribution. The development of acne vulgaris is believed to result from a combination of genetic and environmental factors, including sun exposure, skincare habits, diet, sleep patterns, and psychological stress, all of which can induce or exacerbate the condition. The pathogenesis of acne vulgaris involves androgen-induced sebaceous gland hyperplasia, excessive sebum production, abnormal follicular duct keratinization, microbial colonization, and immune-inflammatory responses. Historically, treatment has focused on regulating sebum production, improving follicular keratinization, and providing antibacterial and anti-inflammatory therapies, with less attention given to repairing the skin barrier. Treatment outcomes have often been suboptimal, with frequent recurrences, high incidence of skin sensitivity, and significant economic and psychological burdens on patients. This review explores the mechanisms of skin barrier impairment in acne vulgaris and discusses strategies for its repair, offering new perspectives for the clinical management of acne.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.