Evidence map›Paper›PMID 39668563›Full record

ReviewPlant communications2025

Synthetic biology and artificial intelligence in crop improvement.

Daolei Zhang, Fan Xu, Fanhua Wang, Liang Le, Li Pu

Abstract readReview
In one paragraph

Review in Plant communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Review
  2. Review
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  4. Artificial intelligence-driven advancements in agricultural biotechnology.Journal, genetic engineering & biotechnology · 2026
    Review
  5. Review
  6. Review
  7. Review
  8. Deciphering Stress Resilience in Black Pepper (International journal of molecular sciences · 2026
    Review
  9. Review
  10. Harnessing polyploidy for climate-resilient crops: Lessons from the evolutionary model, allotetraploid cotton.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Systematic design and evaluation of artificial COSynthetic and systems biotechnology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daolei ZhangBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China; School of Life Sciences, Inner Mongolia University, Hohhot 010021, China.
Fan XuBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China; State Key Laboratory of Tree Genetics and Breeding, Research Institute of Forestry, Chinese Academy of Forestry, Beijing 100091, China.
Fanhua WangBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China; School of Life Sciences, Inner Mongolia University, Hohhot 010021, China.
Liang LeBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China. Electronic address: leliang@caas.cn.
Li PuBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China. Electronic address: puli@caas.cn.

Funding

Non-US Government Research Support type
6 · The paper itself

Abstract

Synthetic biology plays a pivotal role in improving crop traits and increasing bioproduction through the use of engineering principles that purposefully modify plants through "design, build, test, and learn" cycles, ultimately resulting in improved bioproduction based on an input genetic circuit (DNA, RNA, and proteins). Crop synthetic biology is a new tool that uses circular principles to redesign and create innovative biological components, devices, and systems to enhance yields, nutrient absorption, resilience, and nutritional quality. In the digital age, artificial intelligence (AI) has demonstrated great strengths in design and learning. The application of AI has become an irreversible trend, with particularly remarkable potential for use in crop breeding. However, there has not yet been a systematic review of AI-driven synthetic biology pathways for plant engineering. In this review, we explore the fundamental engineering principles used in crop synthetic biology and their applications for crop improvement. We discuss approaches to genetic circuit design, including gene editing, synthetic nucleic acid and protein technologies, multi-omics analysis, genomic selection, directed protein engineering, and AI. We then outline strategies for the development of crops with higher photosynthetic efficiency, reshaped plant architecture, modified metabolic pathways, and improved environmental adaptability and nutrient absorption; the establishment of trait networks; and the construction of crop factories. We propose the development of SMART (self-monitoring, adapted, and responsive technology) crops through AI-empowered synthetic biotechnology. Finally, we address challenges associated with the development of synthetic biology and offer potential solutions for crop improvement.

Indexed as

Artificial IntelligenceCrops, AgriculturalPlant BreedingSynthetic BiologyGene EditingGenetic Engineeringartificial intelligencecrop improvementengineering strategiessynthetic biology

Identifiers

PMID39668563
PMCPMC11897457

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.