Evidence map›Paper›PMID 39669145›Full record

ArticleHeliyon2024

Rehabilitation of N, N'-methylenebisacrylamide-induced DNA destruction in the testis of adult rats by adipose-derived mesenchymal stem cells and conditional medium.

Mona M Atia, Aya Ahmed Badr El-Deen, Hanem S Abdel-Tawab, Alshaimaa A I Alghriany

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mona M AtiaLaboratory of Molecular Cell Biology and Laboratory of Histology, Zoology and Entomology Department, Faculty of Science, Assiut University, 71516, Egypt.
Aya Ahmed Badr El-DeenLaboratory of Molecular Cell Biology and Laboratory of Histology, Zoology and Entomology Department, Faculty of Science, Assiut University, 71516, Egypt.
Hanem S Abdel-TawabLaboratory of Molecular Cell Biology and Laboratory of Histology, Zoology and Entomology Department, Faculty of Science, Assiut University, 71516, Egypt.
Alshaimaa A I AlghrianyLaboratory of Molecular Cell Biology and Laboratory of Histology, Zoology and Entomology Department, Faculty of Science, Assiut University, 71516, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Environmental pollutant acrylamide has toxic effect on human health. Numerous industries such as the paper, and cosmetics, use acrylamide in their manufacturing. In certain foods, acrylamide arises at extremely high temperatures. Mesenchymal stem cells can shield different tissues from the damaging effects of free radicals induced by acrylamide. This study aimed to compare the therapeutic efficacy against acrylamide-induced toxicity between adipose-derived mesenchymal stem cells (MSCs) and their conditioned media (CM), evaluating which is more effective. Seventy adult male rats were employed in this study, distributed among 5 groups. The control group consisted of 10 rats, while each of the other four groups comprised 15 rats. The AC group received a daily oral acrylamide (AC) dosage of 3 mg/kg. In the AC + AD-MSCs and AC + AD-MSCs CM groups, after 4 weeks of AC administration, rats were injected with 0.65 × 10

Indexed as

AcrylamideAdipose-derived mesenchymal stem cellsConditioned mediaDNA damageTesticular toxicity

Identifiers

PMID39669145
PMCPMC11636104

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.