Evidence map›Paper›PMID 39669198›Full record

ArticleFrontiers in pharmacology2024

Role of Rab10 in cocaine-induced behavioral effects is associated with GABAB receptor membrane expression in the nucleus accumbens.

Zhuoxuan Yu, Qiang Fu, Tianyun Qiu, Caidi Yang, Mingfen Lu, Qinghua Peng, Jianhua Yang, Zhenzhen Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhuoxuan Yu *The First Clinical Medical College, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Qiang Fu *Department of Respiration, Department Two, Jiangxi Provincial People's Hospital, Nanchang, Jiangxi, China.
Tianyun Qiu *Department of Clinical Laboratory, Wuhan Hankou Hospital, Wuhan, Hubei, China.
Caidi YangThe First Clinical Medical College, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Mingfen LuDepartment of Pathophysiology, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Qinghua PengDepartment of Anesthesiology, The 1st Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Jianhua YangDepartment of Physiology, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Zhenzhen HuDepartment of Pathophysiology, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: Previous studies have demonstrated that Ras-related GTP-binding protein Rab10 (Rab10) plays a role in psychostimulant-induced behavioral effects. In this study, we showed that Rab10 in the nucleus accumbens (NAc) of male animals affects the development of cocaine-induced behavioral effects, which are associated with the plasma membrane expression of the GABA Methods: We performed flow cytometry, immunoendocytosis, pHluorin activity analysis, electrophysiology analysis, and open-field testing to explore the role of Rab10 in modulating the membrane expression and function of GABA Results: Transcriptomics analysis showed that Conclusion: These results uncover a new mechanism in which Rab10-GABA

Indexed as

behavioral sensitizationcocainegamma aminobutyric acid type B receptornucleus accumbensras-related GTP-binding protein Rab10

Identifiers

PMID39669198
PMCPMC11635607

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.